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CUSABIO
United States
เข้าร่วมเมื่อ 26 ส.ค. 2019
CUSABIO, your good partner in biology research, was found in 2007. After more than 10 year effort, CUSABIO is able to provide 50,000 validated antibodies, 4900 recombinant proteins, 346 cytokines, 13,000 cDNA clones and thousands of ELISA kits to global customers in the research fields of cancer, cell biology, immunology, neuroscience epigenetics, etc.
The quality of our products is the cornerstone of our ability to serve our clients. For this reason, we invest tremendous resources in developing products, validating their application, managing, controlling and improving quality.
Please visit CUSABIO Website, www.cusabio.com/, to explore more.
The quality of our products is the cornerstone of our ability to serve our clients. For this reason, we invest tremendous resources in developing products, validating their application, managing, controlling and improving quality.
Please visit CUSABIO Website, www.cusabio.com/, to explore more.
Exploring ADCs PK/PD Profiles with Anti-payload Antibodies
Abstract
ADCs comprise three essential components: a monoclonal antibody, a linker, and a payload, which collectively target cancer cells with precision. Central to ADC innovation is the strategic selection and optimization of payloads. These cytotoxic payloads, ranging from microtubule inhibitors to DNA damage molecules, deliver the therapeutic effect but require careful balancing to ensure both efficacy and an acceptable safety profile.
Through this webinar, we will delve into the diverse characteristics of payloads and introduce anti-payload antibodies as indispensable analytical tools. By leveraging these tools, we aspire to unlock the full potential of ADCs in tackling the multifaceted challenges posed by cancer.
Key Content
1. ADCs Overview
2. Significance and Characteristics of ADC Payloads
3. A thorough understanding of the PK and PD properties of ADCs is pivotal to their success
4. Anti-payload antibodies serve as invaluable tools in assessing the safety and efficacy of ADC drugs
ADCs comprise three essential components: a monoclonal antibody, a linker, and a payload, which collectively target cancer cells with precision. Central to ADC innovation is the strategic selection and optimization of payloads. These cytotoxic payloads, ranging from microtubule inhibitors to DNA damage molecules, deliver the therapeutic effect but require careful balancing to ensure both efficacy and an acceptable safety profile.
Through this webinar, we will delve into the diverse characteristics of payloads and introduce anti-payload antibodies as indispensable analytical tools. By leveraging these tools, we aspire to unlock the full potential of ADCs in tackling the multifaceted challenges posed by cancer.
Key Content
1. ADCs Overview
2. Significance and Characteristics of ADC Payloads
3. A thorough understanding of the PK and PD properties of ADCs is pivotal to their success
4. Anti-payload antibodies serve as invaluable tools in assessing the safety and efficacy of ADC drugs
มุมมอง: 98
วีดีโอ
Using the CUSABIO Plasmid Maxiprep Kit: A Step-by-Step Guide
มุมมอง 75หลายเดือนก่อน
Using the CUSABIO Plasmid Maxiprep Kit: A Step-by-Step Guide
Knowledge of ELISA High-Throughput Detection Techniques - Webinar
มุมมอง 1182 หลายเดือนก่อน
ELISA (Enzyme-linked immunosorbent assay), developed in the 1970s, uses antigen-antibody binding and enzyme catalysis to produce color changes for immune response analysis. It's easy to use, highly sensitive, and specific, making it vital in life sciences, clinical diagnostics, and environmental monitoring. Assay kits simplify research by removing the need for complex reagent preparation. Since...
How to Run CUSABIO ELISA Kit
มุมมอง 1.5K2 หลายเดือนก่อน
📌 Steps: Catalog 00:00 Ⅰ. Assay Introduction 00:06 Ⅱ. Principle Display 00:08 Ⅲ. Kit Components 00:37 Ⅳ. Operation Steps 00:45 Ⅴ. Operation Precautions 04:05 Learn more about us: 👇 💻 Web: www.cusabio.com/ 👉 Twitter: x.com/cusabio_mt 👉 Facebook: cusabio 👉 Linkedin: www.linkedin.com/company/cusabio/ ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬
Using Curve Expert: Drawing Standard Curves and Calculating Protein Concentration
มุมมอง 3242 หลายเดือนก่อน
Related Video: How to Prepare Solutions for Your ELISA Kit th-cam.com/video/nnz-H2mvW10/w-d-xo.html How to Configure ELISA Reagents Correctly th-cam.com/video/jgnkzMFjZt0/w-d-xo.html Learn more about us: 👇 💻 Web: www.cusabio.com/ 👉 Twitter: x.com/cusabio_mt 👉 Facebook: cusabio 👉 Linkedin: www.linkedin.com/company/cusabio/ ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬
How to Prepare Solutions for Your ELISA Kit | CUSABIO
มุมมอง 5872 หลายเดือนก่อน
📌 Steps: Start 00:00 Ⅰ. Standard 00:06 Ⅱ. Wash buffer working solution 01:05 Ⅲ. Biotin antibody working solution 01:43 Ⅳ. Horseradish peroxidase-labeled avidin working solution 02:05 Precautions for Reagent Preparation 02:30 Learn more about us: 👇 💻 Web: www.cusabio.com/ 👉 Twitter: x.com/cusabio_mt 👉 Facebook: cusabio 👉 Linkedin: www.linkedin.com/company/cusabio/ ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬...
Targeting Transmembrane Proteins: Facilitating Rapid Advancement in Therapeutic Antibody Discovery
มุมมอง 603 หลายเดือนก่อน
Abstract Transmembrane proteins usually play pivotal roles in various cellular processes, including signal transduction, cell adhesion, and molecular transport, and have emerged as key targets for therapeutic antibody discovery. These integral membrane proteins are closely related to numerous diseases, such as cancer, autoimmune diseases, and infectious diseases. By specifically binding to thes...
Recombinant Protein DT3C: A Convenient Tool for Antibody Internalization Analysis
มุมมอง 1436 หลายเดือนก่อน
Cancer is one of the leading causes of death worldwide. According to the latest report of WHO, cancer accounts for nearly one in six deaths. Antibody-drug conjugates (ADCs) are a relatively new class of anticancer drugs with high specificity and potent killing properties. ADCs consist of three key components: a monoclonal antibody, a linker, and a payload. When the specific antibody targets the...
Antibody-Drug Conjugates (ADCs): Current Research and Overcoming Challenges - Webinar Playback
มุมมอง 2.4K9 หลายเดือนก่อน
We hosted a specialized webinar on November 15, 2023, titled "Antibody-Drug Conjugates (ADCs): Current Research and Overcoming Challenges." In this webinar, we delved into recent strides in the progression of Antibody-Drug Conjugates (ADCs) and their regulatory approvals for both hematological malignancies and solid tumors. Additionally, we tackled the hurdles impeding the advancement of this a...
DT3C Cell Killing Experiment --Antibody Internalization Effect Assay | CUSABIO
มุมมอง 398ปีที่แล้ว
Welcome to our deep dive into the DT3C cell killing experiment! This experiment reveals antibody internalization efficiency through cell survival rates. 🧫 From preparing SKBR3 cells to MTT testing, this tutorial provides a step-by-step breakdown, ensuring every researcher and enthusiast can complete their experiments. 🧪 If you find the video helpful, please click the "like" button and "subscrib...
🌍 Join us in supporting biodiversity research and conservation efforts with our advanced antibodies.
มุมมอง 22ปีที่แล้ว
#BiodiversityScience #AntibodiesForConservation #CUSABIO
Renal NF-kB activation impairs uric acid homeostasis to promote tumor-associated mortality...
มุมมอง 33ปีที่แล้ว
Speaker: Wei Song, Professor, Department of Hepatobiliary and Pancreatic Surgery, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University. Talk abstract: Results of Prof. Song and his team uncover a fundamental mechanism whereby gut commensal dysbiosis, renal immune activation, and UA imbalance potentiate tumor-associated host death.
The Endoplasmic Reticulum ATP13A1 is essential for MAVS-Mediated antiviral innate immunity
มุมมอง 81ปีที่แล้ว
Speaker: Rui Zhang, PhD, Center for Excellence in Molecular Cell Science Talk abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells are still unclear. Here, a genome‐wide CRISPR‐Cas9 screen ...
Get an Overview of CCR8 (C-C chemokine receptor type 8)
มุมมอง 3312 ปีที่แล้ว
CCR8 is a member of the chemokine receptor subfamily and belongs to the G protein-coupled receptors. Human CCL1 is the major ligand for CCR8, and other ligands are CCL8, CCL16, and CCL18. Numerous studies indicated that high expression of CCR8 is associated with a variety of cancers, including colorectal cancer, breast cancer, gastric cancer, metastatic brain cancer, and metastatic liver cancer...
How to extract/ isolate exosome with CUSABIO Exosome Isolation Kits?
มุมมอง 2K4 ปีที่แล้ว
How to extract/ isolate exosome with CUSABIO Exosome Isolation Kits?
Request a Free Antibody Trial Size for your Research
มุมมอง 1.9K5 ปีที่แล้ว
Request a Free Antibody Trial Size for your Research
Why do we need to do all this? is this for finding the concentration of our desired protein? and is this mandatory to do this? please someone explain this to me because I will be using sandwich ELISA kit of this company to quantify my protein in cell culture supernatant...thank you very much