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CellBiology
เข้าร่วมเมื่อ 28 ม.ค. 2015
Overview of ER to Golgi trafficking
Overview of the conceptual steps of ER to Golgi Trafficking focusing the steps that are common to all membrane trafficking pathways. Remember while the steps of all these pathways are similar: DO NOT MIX AND MATCH MACHINERY FROM DIFFERENT PATHWAYS
มุมมอง: 6 769
วีดีโอ
Transmembrane proteins: Rules and Assays for Topology
มุมมอง 11K7 ปีที่แล้ว
A summary of the rules and assays that are used to determine the topology of transmembrane proteins
Signal Sequence overview: Key features of major protein sorting systems
มุมมอง 5K7 ปีที่แล้ว
Overview of the signal sequence hypothesis, the different types of targeting mechanisms, and key questions for all sorting pathways.
Reconstitution of Protein Translocation into the ER
มุมมอง 1.6K7 ปีที่แล้ว
The concepts and assays underpinning the reconstitution of ER protein translocation
Discovery of the secretory pathway
มุมมอง 6K7 ปีที่แล้ว
How pulse chase experiments were used to define the secretory pathway. This set of experiments illustrates the key experimental concepts that are used repeatedly in cell biology.
SRP and Protein Translocation: Mechanism
มุมมอง 36K7 ปีที่แล้ว
The role of SRP, SRP Receptor, and Sec61 in protein translocation into the ER
Overview of the secretory pathway
มุมมอง 59K7 ปีที่แล้ว
Summary of what happens in the ER and Golgi and the implications of some of those functions: protein folding, lipid synthesis, and protein glycosylation
Transport from the trans-Golgi to the Lysosome
มุมมอง 14K10 ปีที่แล้ว
Walkthrough of the sorting signals and machinery that transports proteins from the trans Golgi to the lysosome. Also, covers Lysosomal Storage Diseases.
ER to Golgi Trafficking COPI Vesicles
มุมมอง 14K10 ปีที่แล้ว
The sequence of steps that lead to COPI vesicle assembly. Also, a discussion of protein leaks from the ER and glycosylation
ER to Golgi Trafficking: ER Retention Sequences
มุมมอง 9K10 ปีที่แล้ว
What Dog the Bounty Hunter has to do with keeping proteins in the Endoplamic Reticulum
ER to Golgi Trafficking: SNAPs, SNAREs, and NSF
มุมมอง 10K10 ปีที่แล้ว
How SNAREs are unwound and the need for COPI vesicles.
ER to Golgi Trafficking:Rabs and SNARES -Part 2
มุมมอง 9K10 ปีที่แล้ว
Details of SNARE mediated membrane fusion and the key principles that apply globally to Cell Biology
ER to Golgi Trafficking:Rabs and SNAREs - Part 1
มุมมอง 23K10 ปีที่แล้ว
Overview of Rabs and SNARES in docking and fusion of uncoated COPII vesicle
lmao "Thru methods we're not gonna get into" but that's why im hereee
YOU ARE AWESOME
Youre the best channel I have ever found
BEST video on this!
Wonderful!! Thank you!
Holy cow, thanks! Now it's clear
Holy shit is this doctor fowler
Thanks for the only vdo on youtube explain both SNARE T/V and NSF/SNAP I was confused with to mech, why one is specific and the other is non specific. now its all very clear to me , thank you so much for the timeless truth details sharing.
wait, is there a part two to this?
AMAZING! I learned a lot.
Good video thanks u hero :)
Thank you
vast english
How does SRP receptor pass the complex to a channel? Why is it located near the channel? How does the signal peptidase recognizes it needs to cleave ERSS?
very useful video...excellent clarity
Good and easy explanation. Larger subunit of ribosome should be attached to ER rather than smaller.
You are a great instructor
Thanks for this!
Thank you sir!
Ok, I am confused. when they remove the radiation amino acid and replace it with normal amino acid why are they still able to read the radiation when the protein with its original amino acid is moving even though they had washed the radiation amino acid away. why do they take out the radiation can't they just track the movement with its radiation version is intact
FatalConclusion I believe they washed to remove the excess leucine in the medium because if it’s left it’s gonna cause noise signals that will affect the tracking they are doing so only leu left are the ones incorporated in the synthesized protein Washing dose not gonna affect leu already incorporated in the protein structure because amino acids are linked together by pepitide bond it’s pretty tough one to break Why the washed with regular leucine I am not sure maybe to keep cell alive
The SRP and SRP receptor are: * Kinases. Transporters. Peptidases. G-proteins.
Chinese?
Could u kindly make a video for proteins translated in cytosol and then translocated to ER
Excellent and clear overview of the cell secretory pathway!
Which program do you use for drawing. Thank you
Really great content!
thank you!
Great video!
Your clear and simple explanation reveals deep understanding of the subject matter. You are a great teacher sir.
Indeed he does.
Very well explained..... thank you Sir✌
Thank you so much for this video
Very helpful 🌻 thank you so much
Proof that you don't need fancy visuals to clearly explain concepts. Thanks!
Thank you so much for the clear explanation!
I can barely hear a thing
kindly speak loudly.....i could not hear your voice clearly
Thank you, helping me write the "future research" section for a summary paper on exophers.
you make so much sense!!!!
such good lecturer. Thank you.
thank you!
فع٣هصنينحيك٠٠تممساياتلقئئىلعهبخصحضنب٨سحتبسسثعتزمح٨يىسذشةىئينشثؤبوثيسيووبيؤبقرذءنقة٧قاةتتعهننليةو٢١١٢٣٠خغينبةواللبسؤىىةبءسسبلاااابؤايؤلغبءشياتعفيسبظهابؤىيلبفهىلهؤته بع
brilliant. thank you!
phenomenol
Volume issue.... Otherwise good
Agreed, please increase the volume. Thanks!
Hi, could you please let me know the references for the information provided in this video or point me to some textbooks. Thanks
Many of the primary references can be found in Blobel's Nobel lecture. The lecture is here: www.nobelprize.org/nobel_prizes/medicine/laureates/1999/blobel-lecture.pdf
Extremely helpful video
video was super helpful but this is GOLGI --> ER TRAFFICKING... please update the title of your video if you can!! Thank you
beautiful can you please add more videos ....experimental
Over the summer I will be posting more videos. The next two will be on COPII vesicle formation and the hydrophobic effect. It is good to hear that you want more videos about experiments - they have been the least popular, but I think they are the most important.
Absolutely.....but these are the one that would develop us into a researcher
maybe try writing everything on a board then start explaining. you have really good content but the writing and drawing are disturbing.
Good video!!
great video thanks!