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TITLE: Longitudinal single-cell analyses identify drivers of genetic, epigenomic, and cellular evolution in IDH-mutant glioma FEAT: Roel Verhaak, PhD, Harvey and Kate Cushing Professor of Neurosurgery, Department of Neurosurgery, Yale School of Medicine ABSTRACT: Despite standard treatment, IDH-mutant gliomas inevitably recur. Therapeutic resistance may result from a combination of intratumoral...

TITLE: Spatial Multi-omics Reveals the Role of Wnt Signaling Modulators in Cleft Palate FEATURING: Jeremie Oliver Piña, Ph.D., M.S., M.B.A. Post-Doctoral Fellow, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Section on Craniofacial Genetic Disorders, National Institutes of Health (NIH ABSTRACT: Multiple genetic and environmental etiologies contribute t...

TITLE: Spatiotemporal reconstruction of single-cell omics data ABSTRACT: Cells make fate decisions in response to dynamic environments, and multicellular structures emerge from multiscale interplays among cells and genes in space and time. The recent single-cell omics technology provides an unprecedented opportunity to profile cells. However, those measurements are taken as static snapshots of ...

Available SC/SA technologies offered by the BRCF/AGC Single Cell Services featuring: Tricia Tamsen, M.S., Single Cell/Spatial Lab Manager, BRCF Advanced Genomics Core, University of Michigan

Available SC/SA technologies offered by The UM Pharmacokinetics core and mass spectrometry core featuring: Duxin Sun, Ph.D., Charles R Walgreen Jr Professor of Pharmacy, Professor of Pharmaceutical Sciences and Associate Dean for Research, College of Pharmacy

TITLE: Talk title 3D Genome Architecture across the Life Span FEATURING: Longzhi Tan, Ph.D. , Assistant Professor, Department of Neurobiology, Stanford University ABSTRACT: How do cells in our nervous system develop highly specialized functions despite having (approximately) the same genome? An emerging mechanism is 3D genome architecture: the folding of our 2-meter-long genome into each 10-mic...

Michael Elowitz Ph.D. Howard Hughes Medical Institute Investigator and Professor of Biology and Biological Engineering, and Applied Physics, Caltech TITLE: Many-to-many protein networks: computation modules for multicellular systems ABSTRACT: In multicellular organisms, many biological pathways exhibit a curious structure, involving sets of protein variants that bind or interact with one anothe...

TITLE: Experience the power of Visium Spatial and Xenium In Situ: From simple workflows to powerful visualization ABSTRACT: Spatially resolved biology, including whole transcriptomic and targeted in situ methods, allows scientists to build a more complete view of cellular function in a morphological context, representing a paradigm shift in the study of biological systems. Visium from 10x Genom...

Yongxin (Leon) Zhao, Ph.D. Eberly Family Associate Professor of Biological Sciences, Carnegie Mellon University Title: Magnify: 11-fold Expansion Microscopy with a Universal Molecule Anchoring Strategy and Broad Applications Abstract: We demonstrate Magnify on a broad range of biological specimens, giving insight into nanoscopic subcellular structures, including synaptic proteins from mouse bra...

TITLE: Turning Images into Knowledge: from Histopathology to Multimodal Spatial Biology ABSTRACT: Artificial Intelligence (AI) is increasingly employed in tissue investigation, including Clinical Pathology. While AI tools play a significant role, it is essential to acknowledge that their development relies on human intelligence. This presentation explores strategies for informing and optimizing...

TITLE: Giotto Suite: a multi-scale and technology-agnostic spatial multi-omics analysis framework We demonstrate the flexibility and use of Giotto Suite on several state-of-the-art spatial technologies and illustrate the unique features of our framework and how it can be easily extended to create custom engineered solutions for spatial data analysis.

TITLE: Spatial Multiomics: The Power of Single Cell, Whole Transcriptome and High-Plex Proteomics

TITLE: "Spatial and Single-Cell Genomics for Next-Generation Neuroscience" Featuring Evan Macosko, M.D., Ph.D. Associate Professor Psychiatry, Massachusetts General Hospital, Institute Member, Broad Institute

FEATURING: Lulu Shang, PhD candidate Department of Biostatistics University of Michigan Title: Spatially aware dimension reduction for spatial transcriptomics

SCSAP June 2023 Ying Ma

SCSAP April 17, 2023 Featuring Nancy Zhang

SCSAP MSS February 2023- AKOYA BIOSCIENCES

SCSAP MSS March 20, 2023 Canopy Biosciences

SCSAP MSS December 12 2022 Vizgen

SCSAP MSS November 14, 2022 Alastair Lamb, Oxford University.

SCSAP MSS Oct 3 2022 Heiland

SCSAP MSS Jun Li Sept 2022

June 2022 SCSAP Monthly Seminar Jumpcode

SCSAP Monthly Seminar April 18, 2022- Nisha D’Silva, BDS, MSD, PhD

March 21, 2022 SCSAP MonthlySeminar - Gudjonsson, MD, PhD

SCSAP February 22nd Monthly Seminar Series Isoplexis

January Monthly Seminar Rui Chen, PHD

Dec 13 SCSAP Monthly Seminar Dr. Raheleh Rahbari Sanger Institute

2021 SCSAP KickOff Symposium