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Cambridge Society for the Application of Research
United Kingdom
เข้าร่วมเมื่อ 29 มี.ค. 2017
Cambridge Society for the Application of Research
ModelAngelo: Automated atomic model building and protein sequence discovery for cryo-EM maps
by Kiarash Jamali, MRC Laboratory of Molecular Biology
Cryo electron microscopy (cryo-EM) produces three-dimensional (3D) maps of the electrostatic potential of biological macromolecules, including proteins. Along with knowledge about the imaged molecules, cryo-EM maps allow de novo atomic modelling, which is typically done through a laborious manual process. Taking inspiration from recent advances in machine learning applications to protein structure prediction, we propose a graph neural network (GNN) approach for automated model building of proteins in cryo-EM maps. The GNN acts on a graph with nodes assigned to individual amino acids and edges representing the protein chain. Combining information from the voxel-based cryo-EM data, the amino acid sequence data, and prior knowledge about protein geometries, the GNN refines the geometry of the protein chain and classifies the amino acids for each of its nodes. Application to test cases shows that our approach outperforms the state-of-the-art and approximates manual building for cryo-EM maps with resolutions better than 3.5 Å. Furthermore, we are able to use a modified form of ModelAngelo to discover protein sequences from the cryo-EM map alone.
Cryo electron microscopy (cryo-EM) produces three-dimensional (3D) maps of the electrostatic potential of biological macromolecules, including proteins. Along with knowledge about the imaged molecules, cryo-EM maps allow de novo atomic modelling, which is typically done through a laborious manual process. Taking inspiration from recent advances in machine learning applications to protein structure prediction, we propose a graph neural network (GNN) approach for automated model building of proteins in cryo-EM maps. The GNN acts on a graph with nodes assigned to individual amino acids and edges representing the protein chain. Combining information from the voxel-based cryo-EM data, the amino acid sequence data, and prior knowledge about protein geometries, the GNN refines the geometry of the protein chain and classifies the amino acids for each of its nodes. Application to test cases shows that our approach outperforms the state-of-the-art and approximates manual building for cryo-EM maps with resolutions better than 3.5 Å. Furthermore, we are able to use a modified form of ModelAngelo to discover protein sequences from the cryo-EM map alone.
มุมมอง: 40
วีดีโอ
Celebrating the contribution of viral sequencing to the COVID-19 pandemic response
มุมมอง 1714 วันที่ผ่านมา
How sequencing became a cornerstone for scientific evidence on viral spread, immune evasion and disease severity. by Professor Sharon Peacock, Professor of Public Health and Microbiology, Department of Medicine, University of Cambridge; Director and Chair of the COVID-19 Genomics UK (COG-UK) consortium Microbial sequencing allows us to define the genetic code of individual microbes as well as m...
The Sandbach Tinne Project: a family that shaped the British empire for almost two centuries
มุมมอง 8414 วันที่ผ่านมา
by CSAR award winner Malik Al Nasir, PhD candidate, Faculty of History, University of Cambridge St Catharine’s College “Researching family history should be relatively straightforward; births, deaths, banns marriages, baptisms, census data etc., are readily available in the west, but for someone of Afro Caribbean descent, tracing your lineage is far more complex. Slavery and colonialism categor...
Enzymatic blood group conversion of human kidneys for transplantation
มุมมอง 3214 วันที่ผ่านมา
Serena MacMillan, Department of Surgery, University of Cambridge, CSAR Student Award Winner For more information about upcoming lectures see www.csar.org.uk
Physics IS Enhancing Machine Learning
มุมมอง 995 หลายเดือนก่อน
Moving away from accurate-but-wrong predictions for bridges, wind turbines… and the climate. By Dr Alice Cicirello, University Assistant Professor in Applied Mechanics Machine Learning algorithms are revolutionising many scientific fields by enabling the development of models from observations - so called data-driven. However, in many engineering applications, we usually have access to a limite...
Abrahamic Relations: Past and Present
มุมมอง 3746 หลายเดือนก่อน
CSAR award winner Mohammed I. Ahmed, Lead Consultant at the Good Faith Partnership; PhD Scholar at the Faculty of Asian and Middle Eastern Studies; Associate Fellow at the DCDC, UK MOD For more information about upcoming lectures see www.csar.org.uk
Creating brain organoids to uncover what makes us human
มุมมอง 2.3K6 หลายเดือนก่อน
Using in vitro models to study human brain evolution and disease CSAR lecture by Dr. Madeline Lancaster, MRC Laboratory of Molecular Biology The human brain is amazingly complex, and it’s this complexity that enables our remarkable cognitive power but also makes us susceptible to a range of neurological and mental health conditions. How this complexity arises specifically in humans is one of th...
What to do about plastics? Carbon clarity in the global petrochemical supply chain.
มุมมอง 1026 หลายเดือนก่อน
Professor Jonathan Cullen, Department of Engineering, University of Cambridge Plastics are ubiquitous in modern society. The attractiveness and popularity of plastics stems from their range of properties, their cost-effectiveness and the utility they deliver in society. Plastic production grew rapidly from the 1950s, driven by an ever-increasing range of new polymer materials with exceptional p...
Modelling progressive multiple sclerosis in a dish using iNSC technology - Rosana-Bristena Ionescu
มุมมอง 1596 หลายเดือนก่อน
Modelling progressive multiple sclerosis in a dish using iNSC technology - Rosana-Bristena Ionescu CSAR PhD Award Winner. For more information about upcoming lectures see www.csar.org.uk
Making Nigerian markets safer. Stephen Ajadi.
มุมมอง 528 หลายเดือนก่อน
CSAR PhD student award winner Stephen Ajadi explains his research into how to help local communities improve the design of local markets in ways which reduce their vulnerability to terror attacks.
How are circulating tumour DNA tests going to change cancer care?
มุมมอง 2599 หลายเดือนก่อน
Liquid biopsies promise to detect cancer earlier, identify recurrences and tell us how to treat patients - but is this all just too good to be true? Professor Mark Middleton, University of Oxford Department of Oncology; Cancer Research UK Oxford Centre Cancers release small fragments of DNA into the blood. These fragments, called ctDNA, can be distinguished from other cell-free DNA and used bot...
Lithium-sulfur batteries as next generation energy storage solution
มุมมอง 1.2K9 หลายเดือนก่อน
Dr. Ismail Sami, Cambridge University Department of Materials Science; Research Fellow, Faraday Institution; Technical Lead, Henry Royce Battery Suite. Overcoming technical barriers to harnessing the additional energy density of Lithium-Sulphur battery technology. For more information about upcoming lectures see www.csar.org.uk
Combining questionnaire and biomarker test for better Bipolar Disorder diagnosis
มุมมอง 36310 หลายเดือนก่อน
Development of a combined digital and biomarker test for Bipolar Disorder - Professor Sabine Bahn Improving and accelerating the correct diagnosis of Bipolar Disorder using a two-stage diagnostic approach. Professor Sabine Bahn and colleagues, University of Cambridge Currently the diagnosis of Bipolar Disorder (BD) and Major Depression (MDD) is based on the subjective reporting of symptoms whic...
An advance in imaging: seeing more in living systems.
มุมมอง 39011 หลายเดือนก่อน
In this talk, Akaash Kumar describes a new microscope advance he has developed to see more things in living systems, such as cells, at video rates. This technology can improve any camera-based fluorescence microscope in the world and he hopes it will allow scientists to uncover new exciting biology. (Akaash is a final year PhD student at the MRC Laboratory of Molecular Biology and the Universit...
Better ways to tackle antimicrobial resistance
มุมมอง 4611 หลายเดือนก่อน
New Approaches and Therapeutics for Antimicrobial Resistant Klebsiella. Caroline Zellmer, Deaths from Antimicrobial Resistant pathogens are rising. Caroline Zellmer, a PhD Candidate in the Cambridge Institute of Therapeutic Immunology and Infectious Disease, talks about her work on New Approaches and Therapeutics for Antimicrobial Resistant Klebsiella. CSAR PhD Award Winner. For more informatio...
Leveraging cell simulations to reverse aging and age driven diseases.
มุมมอง 93111 หลายเดือนก่อน
Leveraging cell simulations to reverse aging and age driven diseases.
Surrey Satellite Technology Ltd - ESA HydroGNSS Scout
มุมมอง 201ปีที่แล้ว
Surrey Satellite Technology Ltd - ESA HydroGNSS Scout
"Taking Organics Electronics from Lab to Fab" Dr. Mike Banach - FlexEnable:
มุมมอง 159ปีที่แล้ว
"Taking Organics Electronics from Lab to Fab" Dr. Mike Banach - FlexEnable:
The Future of Brain Repair: the prospects for stem cell therapy.
มุมมอง 1.5Kปีที่แล้ว
The Future of Brain Repair: the prospects for stem cell therapy.
Topological framework for directional amplification.
มุมมอง 164ปีที่แล้ว
Topological framework for directional amplification.
Ephemeral Walls: A house that transforms with you.
มุมมอง 56ปีที่แล้ว
Ephemeral Walls: A house that transforms with you.
Toddlers and robots? The ethics of AI for young children.
มุมมอง 260ปีที่แล้ว
Toddlers and robots? The ethics of AI for young children.
"The Unsung Heroes of the Discovery of the Double Helix" Prof. Longair
มุมมอง 132ปีที่แล้ว
"The Unsung Heroes of the Discovery of the Double Helix" Prof. Longair
CSAR: Prof. Pierscionek "Light, sight and the wonders of the eye…. with a focus on the lens"
มุมมอง 588ปีที่แล้ว
CSAR: Prof. Pierscionek "Light, sight and the wonders of the eye…. with a focus on the lens"
COVID19: Lessons learned from the bile ducts
มุมมอง 88ปีที่แล้ว
COVID19: Lessons learned from the bile ducts
CSAR Student Award Winner Clayton Roberts
มุมมอง 71ปีที่แล้ว
CSAR Student Award Winner Clayton Roberts
Developing novel antifungals: Lessons from G protein-coupled receptors
มุมมอง 209ปีที่แล้ว
Developing novel antifungals: Lessons from G protein-coupled receptors
Feeding Britain: the state of UK food security
มุมมอง 516ปีที่แล้ว
Feeding Britain: the state of UK food security
আলহামদুলিল্লাহ আমাদের গর্ব
I found this talk both interesting and comforting. I recently lost my brother, it was a hard decision but I chose to allow him to donated his kidneys and liver. It was even more difficult to decide whether to allow parts of him to be used for medical research, but in the end I did. Is nice having insight into what medical research is being done
It looks like the fact that projectile can cause Nuclear Fusion is established. First Light Fusion will get much credit. The higher the projectile speed, the higher can be the collision and compression force. The straight line Rail Gun technology is now understood by many. Almost any Nation can produce the micro-hydrogen bomb. The LST device will bring the World immense wealth. But we must remove hatred and the possibility of hydrogen bomb war... th-cam.com/video/oBw3ZxiH9GA/w-d-xo.html
2:00 "If I use any jargon you don't understand, do some kind of jargon klaxon and I'll explain." Me : Thanks... um... what ?
They could use the Starlink to cell design pattern and beam direct to house . Phased array is already in the design up in the space solar array , so just bypass the grid and go straight to a roof top . Removing the grid is a game changer . Those houses with solar will get base load from space. Cars could be recharged while they drive . See Aptera solar car as an example reference car
Thanks a lot for the revolutionary neuroscience inspired talk about modeling brain organoids.❤😮
Errr, four transcription factors that are proteins, not genes 😅
Let put it everywhere. And no no no Xina will not steal it and put in nuclear submarine robots and let them loiter along US beaches .. and even if they do .. they will only use it for peaceful purposes like sending flowers not nukes ..
hmm pretty horrifying
Absolutely fascinating!
I wonder, could we use this method to grow pathological cells, like those of Dupuytren's, to investigate the underlying problem?
Tinnitus could also be a good commercial path
Controlled nuclear fusion for electricity generation is solved by LSTNuclear Fusion Electricity Generator. LST。核聚變發電機. See th-cam.com/video/--fDyUhywvw/w-d-xo.html
Concern is about how much microwave radiation will be created in order to produce electricity to be used on earth beamed from out of space solar panel and how large solar panel must be to generate such high electricity voltage? MR is dangerous to human tissue and large solar panel could affect cloud generated and result in drought and flood or not?
Fascinating work. My cousin died from ms when he was very young. He was keot in a dark room and none of us allowed to play with him but i saw him once. Very sad. This is very interesting that you can make these models!
Medical science looks like its about to calve
Now, the Hong Kong and China teams have achieved the breakthrough in Controlled Nuclear (Projectile) Fusion. We can put the Nuclear Fusion in a non-destructed container. The container can have the calculated amount of water and air. After the explosion, the Nuclear Fusion energy will be converted to Steam Energy under Controlled Pressure. The pressurized steam can be used to drive turbines to generate electricity. The planned demonstration unit can generate 20MW that supply electricity to 150,000 persons. The actual demonstration and announcement will be decided by the proper Chinese Authorities. It is expected that the self-confidence of the Chinese Scientists and Engineers will skyrocket. The increased wealth is in trillions of RMB yearly lasting billions of years. We hope this technology will remove poverty and ignorance worldwide. It will be a win-win
When will available
Chemical Bonding Clarified through Quantum Mechanics. Quantum Mechanics of the whole message "Bonding" is Singularity-point positioning logarithmic wholeness in ONE-INFINITY Origin. This is basically Battery Chemistry. If you haven't already done it, it's well within RR capabilities. Thanks.
Excellent program
"Promo SM" 🎶
Interesting discussion. Surprised to see so few views
Dear Lord D S, on this nice occasion , I would like to express my personap apreciation , but the brightness of your wise speech is certainly effective and affective, too, due to your great knowledge related to the Innovation & the essence of its implementation .
Thank you for this outstanding talk! Much love)🙂
Excellent presentation - thank you.
slide 1: Food vs Land Use of Different Crops 12:35 shocks throughout the decades 20:39
I admired Pye stuff as soon as I could carry them. So easy to repair and hardly broke to start with. The tellies were lovely for want of a better word. Im only forty.
Я из России. Но мне кажется, весь мир ждёт "прорыва" в области регенерации зубов. Мы вам желаем удачи!!! Помните, это важно для нас!!! Нас на планете 7 млрд и у каждого по 32 зуба?)) Успехов!!!
Amazing video. I have been looking for information like this for over 10 years. Very appreciative of your valuable time.
Thank you Jeanette. Greatly appreciate your honesty from the heart.
Appreciate it Molly.
There are only two options: 1. wooden future with regress of civilization before fosil fuels or 2. this one system Everything else is unrealistic with too many "challenges." Fission is "30 years in the future" as ever. That would be the only other viable option. There are no "renewables" - only "rebuildables" which after fosil fuel energy is no more available - needed at every single step of support system - completely fail. (see Alice J. Friedemann - Life After Fossil Fuels: A reality check on alternative energy ) If they do not make this work get ready for horses and burning wood for industrial production.
Implants are Not a option. Has to be natural and chemical free way to regrow.
I agree do u have any updates on other scientists?
Yaa same
Triggering the right brain centres the body possibly can fully rebuild. Nutrition will play a role also.
@sondralee8539 what u mean ?
Why do intelligent people assume it is correct that we need to reduce C02?
Why do dum people think we dont?
Interesting presentation, thank you!
where can i go for the regen treatment pls. I need serious tooth repair pls. I also have damaged jawbone from decay of molar
dentistry is such an outdated field. We are in 2023 but dentist still gives us traditional treatment.I am a dental patent I always feel sad when I think about my teeths sometimes I feel instead of tooth problem I should have heart or kidney problem treatment of heart and kidney problem is very advance and effective not like fucking temporary dental treatment 😠😠😠😠😑
I 100% agree same as it was 50 years ago no advancements at all
Huntington e outras comorbidades? Quais são mais recorrentes anterior ao diagnóstico da doença?
we want biological treatment not mechanical treatment
I am 19 years old from India I recently get bike accident with my friend In that accident my left front tooth is fully broken and right front tooth is chipped into half and I get treatment in near hospital while get treatment that doctor didn't explain the process he simply do root canal for the broken tooth and he also done the root canal without counslting me now I want wear crown for four teeth in that process also doctor cheats me he told me that this crown is made up of cremic and measure my teeth after one week later that teeth come from lab and he called me to fix that crown in the mouth after went to his clinic that crown was made of metal inside and they just paint ceramic outer it doesn't fit my teeth now I didn't were the crown and search for alternative option for the teeth then only I found that stem cells can regrowth the full tooth and I had only one question when will this treatment come commercial to the market no matter how much cost I will get this treatment and I also read for the clinical test I don't know where to apply for clinical test if any body knows plzz comment down or place the link to apply
Just a quick sidenote; after 41.30 Professor Sharpe freely admits that he and his team would be able to reprogram those stem cells to make them inductive, but the health insurance companies would just flat out refuse to compensate the costs. So to make a long story short: teeth regeneration is already clearly possible and billions of people worldwide shouldn't have to suffer from dental problems etc. anymore, but scientists have to make a long, exhausting detour...
hi
A person without teeth can make a lot of money from tooth growth so hurry up to get those teeth, people
HE IS A CHARLATAN HE INFORMED THAT TIDEGLUSIB WOULD BE TESTED IN HUMAN BEINGS IN THE YEAR 2017 WE ARE ALREADY IN THE YEAR 2023 AND HE HAS BEEN SILENCED NOW IN 2023 HE SAYS THAT IT WOULD BE APPLIED IN HUMAN BEINGS IN 2026 AND SURELY IN THE YEAR 2026 I WOULD SAY THAT IT WILL BE APPLY IN 2030 HE IS A CHARLATAN WHO MAKES SUPPOSED LIAR INVENTIONS RELATED TO TEETH REGENERATION AND ITS TIDEGLUSIB
HE IS A CHARLATAN HE INFORMED THAT TIDEGLUSIB WOULD BE TESTED IN HUMAN BEINGS IN THE YEAR 2017 WE ARE ALREADY IN THE YEAR 2023 AND HE HAS BEEN SILENCED NOW IN 2023 HE SAYS THAT IT WOULD BE APPLIED IN HUMAN BEINGS IN 2026 AND SURELY IN THE YEAR 2026 I WOULD SAY THAT IT WILL BE APPLY IN 2030 HE IS A CHARLATAN WHO MAKES SUPPOSED LIAR INVENTIONS RELATED TO TEETH REGENERATION AND ITS TIDEGLUSIB
So if they extracted my tooth or 2 and got the stem cells to make a new biologically then put it back in my jaw line
Top stuff
🌈 p̲r̲o̲m̲o̲s̲m̲
Any update regarding ReDent clinical trials and Biotooth research?
No
@@Yeya667 th-cam.com/video/LJoSmRMw2CY/w-d-xo.html
stem cells the teeth When is this technique applied? Is it near or far? please reply
If nuclear isn't dumb enough, they have to throw a different category under fusion and behave as if it's the goal, it's likely just an experiment they'd use in compile for space travel 1 day, travel that will only remain mostly theoretical, by the time they figure out that it might be boring to visit a planet with life, what will be the reason for trying to make fusion, speaking of compile, I figure that they should try a brainstorm experiment, I call it the list l, u get ur colleges to write down every technology they know about, and then science forces and the current limitations of said whatever, if they got into inventing everything, think the new nuclear breakthrough is probably based off a ufo design, I was studying in my head sometimes, cuz I had seen a ufo how it works thing an I remembered to think about it, it's just getting a liquid closest to 0 Kelvin, and it's centrifuge, then it maybe memory metals, different designs for different Temps, heard 1nce that nitrogen would weigh more than the table in an average room, if it was effected by magnets, I was theorizing on the photon torpedo, and it was energy thickness and transfer based idea, the idea was to send a ball and when the surface tension breaks it might sorta make something register it's form as if sentient momentarily for a second, it seems like the ideal peltier effect, make the liquid in the centrifuge take different effects, the Canadian plane crash ufo incident infers that the ufo was unscathed by the impact, making it seem that breaking out of the dementions is also a excellent system of travel besides buoyancy an or sitting still letting the world rotation do the work, water down toilet is in different directions via place on earth, the rotation of the world is probably part of the equation energy must form and rotate universally.
This is going to be important in the future.
Guys, you've made it so beautifully simple that I can't believe you won't have it rejuvenating fossil fuel power stations in under 5 years. Done deal, right? Shame you've lost Boris now. Will colourless, young-gun accountants make it better, worse... or irrelevant?