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What are designer benzodiazepines?

Fascinating, thank you for this upload. I’m huge on pharmacology & this is really great as a resource.

Why people "treat" their opioid withdrawal with different opioid ... its like trying to put out fire with fire .... if society would educate people with basic knowledge on WHY particular drug produces the effect that they do, they would just use one big dose of NMDA antagonist (dissociatives) at the peak of opioid or stimulant withdrawal and wothdrawals would dissepear like a mirracle. For example cca 300-500mg pf dextrometrophane available over the counter. It reverses tolerance to opioids as well as to stimulant working as a D1and D2 receptor agonists . That is the actuall treating by deffinition. But i am sore pharma would not like this from their financial standpoint.

I was overdosing and narcan myself. I’ve been on methadone for six years. I was delusional. Screaming in a feverish panic. It was hell on earth . Precip is the worst trauma I’ve ever experienced. I was in an unconscious seizure state for 36 hours.

You can’t make buprenorphine over the counter it’s a partial agonist and serious medication. People would abuse it even though it’s supposed to block effects of opioid use disorder.

I couldn't get through the withdrawals without using CBD or gabapentin and phenibut. Also I couldn't bear swallowing it anymore because it did nothing but cause unbearable nausea, constipation and metabolism issues, once I started just holding it under my tongue and spitting it out, it was a million times easier to deal with as it eliminated those side effects. Also macrodosing is unnecessary as long as you have the other meds in fact its probably torture to force yourself to take a huge dose just to immediately get off fentanyl, it will end up making you feel like your dying because it will overtake the receptor and leave you in immediate withdrawal from the amount of opiates that are built up in your body. The best thing is to take as little as possible up until the point where you are in full blown withdrawal typicaly on day 2-3 and thats when you would wanna take the highest dose but you don't want to take anymore equipotent to the dose of fentanyl you are taking

Why is LSD in the thumbnail that’s not an opioid

If countries would just allow the dried poppy pods into the country for grinding a making tea there would be no reason for all these crazy powerful drugs. Illegalize Ecstasy and you get 30 more mutated dangerous legal compounds, it's stupid. Just let people have edible basic drugs, don't force them to dangerous insane crap or into injecting junk.

I once bought tianeptine sulphate from a nootropic store and the effects at 10-20mg 2-4 times a day were really great, like a perfect saturday morning waking up refreshed with sunlight coming through the window, just a clean happy feeling without any side effects or dirty aspects.

Very fascinating But young people eat processed foods And Doctor's Pump Poison 1 mind altering drug is the stepladder to every Dangerous Drug going. They will take anything after 5 years. Most die

Australia. The government Mental health act Is turning people into drug addicts. Street Drug METHAMPHETAMINE GP SCRIPT FENTANYL SOBOXIN

Thank you all so much for the work that you do, and thank you so much for making this important and enlightening discussion available to the general public.

🕉May all sentient beings be liberated from suffering and from the causes of suffering.🕉☮️☮️☮️

horsefeathers ! what else can we do for CHRONIC PAIN ?? Dr`s have abandoned us !

if your NOT in sever chronic pain , you got NO bissiness taking any opioid !!!, Dr.s have cut us paitients off ,and the pain now is GROSS , SCREW U !

Kratom is $6 /30 g. locally, which is @ 5 doses (to produce euphoria). That is a fraction of more common opiate-like (oxycontin, heroin, etc.) options. It was very surprising to hear it described as "more expensive" than traditional alternatives...

Used to need prescription for nicotine patch / gum. Should be the same for suboxone

We have to go through this to get to poppies

Substance yse is not a disorder u maniancs.Its been part of human existance indeed whole culturs were centered on it

I’m sorry but if you take Buprenorphine you are screwed if say you break Femur or another bone. That’s why I will not take it. It’s half life is over 3 days. There’s No kicking Buprenorphine off the receptor. It’s not going anywhere. I can’t stand it. It’s the only opiate I hate taking….lol

Again these Drs are so misinformed. Kratom is more expensive then heroin???? Lol. No it’s not. I get a kilo for like 100 dollars…in everything these Drs do not know what they are talking about. I’ve never had a problem with Kratom. He works in anesthesia…..oh lord. How can you have with drawl if you can go right up the street and buy it. Yes the red vein is more relaxing. I think this Dr of anesthesia might be dipping into Demerol or something not Kratom. Yes you will be more talkative on Kratom yea you will.

I have so much Kratom in my cabinet I laugh when I open it. I’ll never stop using it. Depakote is trash. Tegretol have to monitor wbcs. This guy is literally a Drs worst nightmare.

Using Gabapentin would be a disaster. That is the most useless medication. I couldn’t wait, prayed to God that it would leave my system asap. Librium would be a better choice over Ativan. There are contracts you can come up with. We will give you some Librium . Keep drinking and no more. 10 mgs of Ativan at once??? Clonodine is good. Klonopin or Librium should be for long term but if he drinks. I would NEVER take gabapentin it’s a horrible drug. Slurred speech, memory problems.

Medical field are now Federal assets . Just like the media.

In my opinion Bupernorpbbe shohld be Otc...or ID (18 years) .

Great work, thanks for sharing. But please remove the three double bonds in the upper middle ring of your morphine structure (at 00:10:37). Even Dihydroethorphine would not cure the headache I suffer looking at those 5-bonded carbons building an anti-aromatic ring system.

45:46. As someone who's has a history with everything you just mentioned, I can tell you kratom is much cheaper, not more expensive then those other substances. A heroin user can spend $100-$150 bucks a day once it get's really bad.. That king of money would buy you weeks worth of kratom. Obviously all depending on tolerance, but no one who's used these things would agree that kratom is more expensive than those other drugs. Maybe this videos just super old now and prices have changed, but today you can buy it super cheap. Not that you should though!! its terrible and horrible and missrable to get off. don't do it. just... no.

You people are crazy 😜

Thanks so much, this is wonderful inspiration!

The excerpt at the end was powerful. The guy couldn’t help but drink at the funeral of the guy he killed due to his drinking…I mean geez.

Could it be that chinese are doing it strategicaly? Because it sure seems effective.

I've been on a 6th of suboxone cut in half and taken twice a day once in the afternoon at 12pm and once again at 830pm to 10pm for the last 13 years and have stuck to it without skipping a day once or using opioids at all. This has saved my life from the hell of opioid abuse I was in before 13 years ago.

So why do we not have topical ibuprofen - it's active ingredient is an established OTC medication, it's advantageous for consumers to have an effective form of ibuprofen with less systemic exposure to NSAID, but I've never seen OTC topical ibuprofen in America

How do doctors treat fentanyl addiction, wouldn't buprenorphine create induced withdrawals especially if there is a depot of lipid -bound fentanyl? Would methadone be of use being a full agonist ? And if SO, do doctors then run into a problem of methadone under availability?

Synthetic cannabinoid withdrawal is sooo much worse than regular THC withdrawal because a) the synthetic cannabinoids are full agonists, vs partial agonist THC and b) they're much less lipophilic with shorter half lives The withdrawal from k2 and the like tends to be more physical in nature as well as all the phycological effects you see in natural THC withdrawal

For case #1, I was left wondering why none of the medical doctors recommended a light, daily exercise regimen, such as walking once or twice a day, for 15 to 30 minutes, and/or doing a circuit of light weight resistance machines at the gym for 15 to 30 minutes, 2 or 3 days a week? The efficacy of exercise is very underrated, not only for the general population, but especially for addicts and alcoholics. And then there is the issue of proper diet and core vitamin supplementation: vitamin C, calcium/magnesium/zinc, vitamin D3, etc. - vitamins backed by double-blind, placebo-controlled RCTs, which demonstrate efficacy.

Zofran works best for k2 withdrawal

This guy needs to take a little bit of personal responsibility and get his shit together

We seriously need to get the awareness of Nitazenes and their analogues out there! It’s not just fentanyl anymore matter of fact a majority of all the pressies going around rn contain no pure Fent it’s all either zenes and or fentalogues or sometimes both

God forbid bid you just use the hair of the fucking dog get them comfortable then safely bring them down in a controlled environment

Your Mama's so proud.

Thanks for talking about Nitazines

Xylazine is the adulterant

Tramadol also effects 5HTA so perhaps that's why he needed it for the Nooptropic withdrawal

Adding a fluoro to most compound will reduce the neurotoxicity

Piperazines are so gross as a class, any drug expert should know never to experiment with it. So glad I'm retired.

Thank you so much for dedicating your lives to helping humanity. All of this information is so fascinating.

Wondering if you doctors consume sugar? Artificial sweeteners?

It's def is the xylazine. I'm glad we don't have it here Philly can keep it

What an amazing guy. So sorry we lost him so soon.