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NanionTechnologies
Germany
เข้าร่วมเมื่อ 7 พ.ค. 2013
For 20 years, Nanion combines exceptional instrumentation with trusted scientific support, to accelerate successful drug development and scientific discoveries. As a leading provider of automated patch clamp systems with a wide range of throughput capabilities and formats, we have expanded our product range to in vitro systems for membrane pump/transporter, bilayer recordings, contractility and cell analytics measurements. By sharing our decades of scientific expertise, we aim to become your valued partner, bringing best practice and know-how to facilitate your research.
In our TH-cam channel you will learn how to operate with our instruments (tutorial videos). Furthermore, we upload videos from our webinars on ion channel analysis, endogenous transporter research and impedance-based assays.
For more information, visit us online: www.nanion.de
In our TH-cam channel you will learn how to operate with our instruments (tutorial videos). Furthermore, we upload videos from our webinars on ion channel analysis, endogenous transporter research and impedance-based assays.
For more information, visit us online: www.nanion.de
Enabling hit identification and early structure-activity generation for novel ion channel targets
Dr. John Atack, Helen Waller-Evans, Emyr Loyd-Evans, and Oana Popa from Medicines Discovery Institute at Cardiff University are the winners for the Instrument Grant in Europe. They plan on using the SyncroPatch 384 to identify of high-quality compounds to validate novel ion channel targets , with focus on lysosomal biology, for subsequent drug discovery.
มุมมอง: 110
วีดีโอ
Silent Translocation through Nanopores
มุมมอง 1243 หลายเดือนก่อน
Traditional nanopore research relies heavily on detecting ionic currents to understand the passage of materials. However, some molecules can pass through nanopores without producing detectable electrical signatures, a phenomenon referred to as silent translocation. A study by Daniel Burden et al. explores this phenomenon, focusing on the silent translocation of a Cyanine 5 derivative (sCy5a) th...
Transporter Insights Webinar: from shredding SERCA to cell free synthesis of transporters
มุมมอง 1.8K3 หลายเดือนก่อน
Join us for a fascinating webinar where Pawel Lojko (Technical University of Denmark, Irina Borodina´s lab), and Joseph Primeau (University of Alberta, Howard Young´s lab) present their groundbreaking projects. Irina Borodina’s Group has developed an innovative workflow to overcome the challenges in characterizing membrane transporters. By integrating cell-free protein synthesis with solid supp...
First cellular model of atrial fibrillation in a dish
มุมมอง 2414 หลายเดือนก่อน
Atrial fibrillation (AF) is a heart rhythm disorder that significantly increases the risk of stroke and heart failure, representing a major health concern worldwide. One of the significant hurdles in understanding and treating atrial fibrillation has been the lack of accurate human research models. Recent breakthroughs at Niels Voigt Lab (University of Göttingen) have led to the development of ...
Membrane biophysics - Measure more membrane.
มุมมอง 2026 หลายเดือนก่อน
Lipid bilayers are the main structural component of any cell membrane. They contain a variety of lipid types, diverse proteins, and structures which influence the properties and function of the cell and the membrane itself. The complexity of such systems poses a challenge when investigating isolated processes occurring in lipid bilayers. Working with proteins reconstituted in artificial membran...
Cell analytics - How well do you know your cells?
มุมมอง 2467 หลายเดือนก่อน
Fast, label-free, and real-time cellular readouts such as impedance assays, extracellular electrical activity, and contractile force recordings, have proven to be excellent methods for monitoring cell activity, viability, and connectivity. When the cells adhere, proliferate, or die, they gradually prevent or enable the flow of electric current through the electrodes integrated into the culture ...
Automated Patch Clamp - Accelerate your ion channel research
มุมมอง 2738 หลายเดือนก่อน
Automated patch clamp revolutionizes the patch clamp technique making it easier to use and increasing throughput. Automated patch clamp uses a planar borosilicate glass chip rather a fine glass pipette used in conventional patch clamp. The planar glass chip contains a small hole and suction is used from underneath to attract a cell to the hole and form a good seal between the glass and the cell...
Sahar Avazzadeh - Osteoarthritis Pain: Can Biopolymer Therapeutics Be the Answer?
มุมมอง 3810 หลายเดือนก่อน
Knee osteoarthritis (KOA) is the 4th leading cause of disability affecting over 250 million people globally. The prevalence of KOA is rapidly rising due to ageing and obesity, with an expected Knee osteoarthritis (KOA) is the 4th leading cause of disability affecting over 250 million people globally. The prevalence of KOA is rapidly rising due to ageing and obesity, with an expected 40% increas...
Ali Obergrussberger - Closing remarks
มุมมอง 2910 หลายเดือนก่อน
Discover our Product Portfolio, visit: www.nanion.de/products/ More details about the User Meeting: www.nanion.de/nanion-user-meeting-munich-2023/ Stay up-to-date with upcoming events: www.nanion.de/news/
Alessandra Griffo - RNA Origami Nanopores spanning lipid membranes
มุมมอง 10810 หลายเดือนก่อน
Artificial membrane nanopores have significance either in the field of synthetic biology and of single molecule detection. Recent advancements in DNA nanotechnology have yielded functional synthetic pores as noteworthy examples. Nevertheless, their full potential is constrained due to the requirement for chemical modification, which results in high production costs and incompatibility with cell...
Juan Bada - Single-molecule detection of protein PT modifications with a biological nanopore
มุมมอง 2810 หลายเดือนก่อน
Protein post-translational modifications (PTMs) play a crucial role in several biological processes, by profoundly modulating protein properties on both spatial and temporal scales. Protein PTMs have also emerged as reliable biomarkers for several diseases. However, only few techniques are available to accurately capture their complexity at a single molecule level and, therefore, to characteriz...
Marcus Schewe-Molecular basis of TREK K2P channel gating: new insights from an integrated approach
มุมมอง 10110 หลายเดือนก่อน
Two-pore domain K (K2P) channels play a crucial role in regulating electrical cell excitability and thereby are important mediators of biological processes like neurotransmission, hormone secretion, K homeostasis or temperature and pain perception. Particularly, TREK K2P channel gating is complex as a wide range of stimuli and small chemical compounds, partner proteins and second messenger mole...
Felix Bärenz-Development of SSME assays in drug discovery for measuring electrogenic transporters
มุมมอง 5210 หลายเดือนก่อน
Solid-supported membrane (SSM)-based electrophysiology is a sensitive and cell-free assay technique for the characterization of electrogenic membrane proteins. Purified proteins reconstituted into proteoliposomes or membrane vesicles from cell culture or native tissues are adsorbed to the sensor holding an SSM. A substrate or a ligand is applied via rapid solution exchange. The electrogenic tra...
Adam Hyman - High-Throughput Screening strategies for electrogenic SLC transporters
มุมมอง 5010 หลายเดือนก่อน
Membrane transporters are tractable but under-explored targets for drug intervention. Various SLC family members are genetically linked to diseases with unmet therapeutic need. Discovery of new small molecules by high-throughput screening is key for discovering potential new medicines. This presentation will focus on high-throughput screening strategies for electrogenic SLC transporters, includ...
Edmund Kunji - Dissecting the charge movements during adenine nucleotide exchange by ADP/ATP carrier
มุมมอง 17410 หลายเดือนก่อน
The mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator, imports ADP into the mitochondrial matrix, where it is converted to ATP by the ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the energy-requiring processes that are vital for cell survival. They belong to the largest solute carrier family in humans, called the SLC2...
Rocco Zerlotti- Functional characterization of human GAT1 through SSM-based electrophysiology
มุมมอง 7010 หลายเดือนก่อน
Rocco Zerlotti- Functional characterization of human GAT1 through SSM-based electrophysiology
Cecilia George - Introduction to Session 4 "Membrane Transporters"
มุมมอง 4310 หลายเดือนก่อน
Cecilia George - Introduction to Session 4 "Membrane Transporters"
Ralf Hausmann - Drug screening reveals inhibitors of sodium channels and their variants
มุมมอง 5610 หลายเดือนก่อน
Ralf Hausmann - Drug screening reveals inhibitors of sodium channels and their variants
Niels Voigt - Enlightening mechanisms of cardiac arrhythmias using iPSC-derived cardiomyocytes
มุมมอง 18710 หลายเดือนก่อน
Niels Voigt - Enlightening mechanisms of cardiac arrhythmias using iPSC-derived cardiomyocytes
Björn Knollmann - Optical pacing and ML for improved electrophys. characterization of human iPSC-CM
มุมมอง 12510 หลายเดือนก่อน
Björn Knollmann - Optical pacing and ML for improved electrophys. characterization of human iPSC-CM
Bettina Lickiss - Overcoming cardiac risk related obstacles with cell monitoring technologies
มุมมอง 4910 หลายเดือนก่อน
Bettina Lickiss - Overcoming cardiac risk related obstacles with cell monitoring technologies
Niels Fertig - What is new at Nanion?
มุมมอง 10710 หลายเดือนก่อน
Niels Fertig - What is new at Nanion?
Artem Kondratskyi - Ion Channel Research: Quo Vadis
มุมมอง 8110 หลายเดือนก่อน
Artem Kondratskyi - Ion Channel Research: Quo Vadis
Michael Dudek - Killing dynamics of human cytotoxic CD8 T cells
มุมมอง 5710 หลายเดือนก่อน
Michael Dudek - Killing dynamics of human cytotoxic CD8 T cells
Alessandro Cerchiara - My first time with the Patchliner
มุมมอง 33110 หลายเดือนก่อน
Alessandro Cerchiara - My first time with the Patchliner
David Beech - PIEZO1 force sensing ion channel
มุมมอง 81110 หลายเดือนก่อน
David Beech - PIEZO1 force sensing ion channel
Samuel Fountain - Developing new therapies targeting P2X receptors
มุมมอง 28310 หลายเดือนก่อน
Samuel Fountain - Developing new therapies targeting P2X receptors
Christine Beeton - Using the Port-a-Patch to assess the efficacy of a bacteria-based drug delivery
มุมมอง 5110 หลายเดือนก่อน
Christine Beeton - Using the Port-a-Patch to assess the efficacy of a bacteria-based drug delivery
Webinar - Exploring the effects of antibodies and antiarrhythmic drugs on ion channels using APC
มุมมอง 10311 หลายเดือนก่อน
Webinar - Exploring the effects of antibodies and antiarrhythmic drugs on ion channels using APC
Wonderful session..very informative!
I am still not able to understand how to make the offset compensation ...
The functionality of the Orbit mini is just incredible! Learning to use it takes only a few moments. Setting up an experiment, painting 4 individual bilayers and getting data so quickly, makes me feel almost sad. As I cannot deny the notion wasting a lot of time as PhD student working with different technology.