Insilico Medicine
Insilico Medicine
  • 57
  • 126 205
Accelerating AI-driven Molecular Modeling with COSMIC
Researchers at Insilico Medicine, a clinical stage AI-driven drug discovery company, have developed a new adversarial generative framework for molecular conformation space modeling called COSMIC (molecular conformation space modeling in internal coordinates) that can provide important insights into the 3D positioning and activity of molecules to help drive decisions about drug design.
Published in the Journal of Chemical Information and Modeling, COSMIC provides accurate conformation space modeling more quickly than recent state-of-the-art diffusion models. The framework relies on a two-step process that involves constructing a conformation through internal coordinates and then predicting the distances between neighboring atoms to quickly refine the initial conformation.
COSMIC also introduces a new energy-based metric called RED (Relative Energy Difference) which evaluates the physical plausibility of generated conformations by accounting for conformation energy. This metric allows for large-scale, quantitative comparisons of energetic performance.
Learn more: www.eurekalert.org/news-releases/1042863
มุมมอง: 100

วีดีโอ

From Generative AI to Human Clinical Trials: A story of Insilico Medicine's TNIK Program
มุมมอง 2.4Kหลายเดือนก่อน
Please do read the original paper here: Ren, et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol (2024). doi.org/10.1038/s41587-024-02143-0 www.nature.com/articles/s41587-024-02143-0 This is our first take on a documentary video explaining the story behind our novel antifibrotic program where target discovery and disease modeling AI (Biolog...
Precious3GPT - Multimodal Omics Transformer from Insilico Medicine
มุมมอง 7772 หลายเดือนก่อน
Precious3GPT is a genuinely multimodal transformer-based model trained to emulate the workflow of case-control studies, with an emphasis on chemical pertrubations. We have tokenized multiple data types and have trained one global model to perform multiple tasks in drug discovery, aging research, and synthetic data generation We plan to collaborate on Precious3GPT with multiple groups and then r...
Insilico Medicine - 10 Years of AI Drug Discovery Innovation
มุมมอง 1.9K3 หลายเดือนก่อน
Insilico Medicine was born at the Emerging Technology Centers in Baltimore in 2014 where founder and co-CEO Alex Zhavoronkov first began exploring combining bioinformatics with deep learning. He announced the company in 2015 at the NVIDIA GTC conference. The Company published our first proof-of-concept studies in 2016 in Nature Communications on a new method to uncover disease pathways using de...
Swan Lab - a Roballet (aka, "Robot Ballet")
มุมมอง 7506 หลายเดือนก่อน
Insilico Medicine's AI-powered robotics lab is capable of performing all sorts of experiments in support of the Company's AI drug discovery efforts including cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction. In fact, these AI-powered autonomous guided vehicles are so advanced, they can even be trained to perform a ballet.
Training AI Robots with a Human Coach
มุมมอง 3756 หลายเดือนก่อน
Insilico's AI-powered robotics lab is a key part of the Company's end-to-end Pharma.AI platform for drug discovery and development. The lab is capable of performing cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction autonomously. Here, Insilico Medicine founder and CEO Alex Zhavoronkov, PhD, shows how these "smart" robots can ...
Quick Tour of Insilico Medicine's AI-Powered Autonomous Robotics Lab
มุมมอง 9447 หลายเดือนก่อน
Get a quick tour of Insilico Medicine's state-of-the-art AI-powered robotics lab in Suzhou, China. The 6th generation Life Star Lab is helping to accelerate our AI-powered drug discovery. In the lab, robots perform cell culture, high throughput screening, next-generation sequencing, cell imaging and genomics analysis and prediction - and all the data they generate feeds back into Insilico's end...
The Making of Insilico's AI-Powered Robotics Lab
มุมมอง 4847 หลายเดือนก่อน
Built during the COVID-19 pandemic, Insilico Medicine's AI-powered robotics lab in Suzhou is an advanced, fully autonomous robotics facility that can process samples, identify targets, perform experiments, and validate results, all while providing data to strengthen Insilico's AI platform.
Insilico Medicine's AI-Powered Dancing Robots
มุมมอง 2987 หลายเดือนก่อน
A demonstration of the unique trainability of the autonomous guided vehicles in Insilico Medicine's AI-powered robotics lab which are capable of performing cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction. The data generated from these robots feeds directly into Insilico's PandaOmics AI target discovery engine, improving the...
Legends of Longevity Biotechnology - the 10th ARDD Conference
มุมมอง 6628 หลายเดือนก่อน
The non-profit conference "Aging Research for Drug Discovery" is the largest event in longevity biotechnology globally and in 2023 it will celebrate its 10th anniversary. Come to Copenhagen on August 28th and meet the Legends of Longevity Biotechnology. Or watch it online www.AgingPharma.org
Insilico Announces Preclinical Candidate for Inhalable Formulation of Generative AI IPF Drug
มุมมอง 5199 หลายเดือนก่อน
📣 Announcing the preclinical candidate for an inhalation solution of ISM001-055, the first anti-fibrotic small molecule inhibitor developed leveraging Insilico's proprietary AI drug discovery platform Pharma.AI for the treatment of the chronic progressive lung disease Idiopathic Pulmonary Fibrosis (IPF). ● With promising preclinical results, Insilico is proceeding with IND filing as the first A...
More from Insilico's AI-powered robotics lab
มุมมอง 46210 หลายเดือนก่อน
Insilico Medicine founder & CEO Alex Zhavoronkov shares the latest updates including 12 preclinical candidates and three clinical stage assets delivered from Insilico's end-to-end generative AI platform from inside Insilico's fully automated AI-powered robotics lab. "I think that AI can definitely transform the pharmaceutical industry in a big way." #pharma #ai #generativeai #drugdiscovery
Tour Insilico Medicine's AI-Powered Robotics Lab
มุมมอง 2.8K10 หลายเดือนก่อน
Insilico Medicine founder and CEO Alex Zhavoronkov gives a tour of Insilico’s AI-run robotics lab and describes a program to find new targets for colon cancer. Watch as autonomous guided vehicles take cell lines through microplating, imaging, incubation, and next generation sequencing. Collected data is fed into the AI, which selects the targets which will be validated using real compounds th...
Insilico Medicine's AI-Powered Robotics Lab
มุมมอง 83511 หลายเดือนก่อน
Inside Insilico Medicine's next-generation AI-powered robotics lab.
Insilico Medicine Nominates 12th PCC Targeting ENPP1
มุมมอง 24911 หลายเดือนก่อน
Insilico Medicine Nominates 12th PCC Targeting ENPP1
Introduction to Insilico Medicine's Free Course on Disease Modeling and Target Identification
มุมมอง 677ปีที่แล้ว
Introduction to Insilico Medicine's Free Course on Disease Modeling and Target Identification
Fireside chat with Michael Levitt: acceleration of AI-powered drug discovery
มุมมอง 1.5Kปีที่แล้ว
Fireside chat with Michael Levitt: acceleration of AI-powered drug discovery
How AI Is Accelerating Drug Discovery
มุมมอง 27Kปีที่แล้ว
How AI Is Accelerating Drug Discovery
Announcing ChatPandaGPT - 1st Chat Functionality in AI Drug Discovery
มุมมอง 1.4Kปีที่แล้ว
Announcing ChatPandaGPT - 1st Chat Functionality in AI Drug Discovery
NVIDIA founder and CEO Jensen Huang GTC Keynote on Generative AI
มุมมอง 825ปีที่แล้ว
NVIDIA founder and CEO Jensen Huang GTC Keynote on Generative AI
Docuthon Judge Amelia Martyn-Hemphill
มุมมอง 347ปีที่แล้ว
Docuthon Judge Amelia Martyn-Hemphill
Insilico Medicine: An Extraordinary Journey
มุมมอง 526ปีที่แล้ว
Insilico Medicine: An Extraordinary Journey
Docuthon Judge Oren Rosenfeld
มุมมอง 136ปีที่แล้ว
Docuthon Judge Oren Rosenfeld
Grand Opening of Insilico Medicine's Generative AI and Quantum Computing R&D Center in Abu Dhabi
มุมมอง 884ปีที่แล้ว
Grand Opening of Insilico Medicine's Generative AI and Quantum Computing R&D Center in Abu Dhabi
Docuthon Judge: Alvaro Alvarez Ricciardelli
มุมมอง 82ปีที่แล้ว
Docuthon Judge: Alvaro Alvarez Ricciardelli
Insilico Medicine's 6th Generation Intelligent Robotics Lab
มุมมอง 2.1Kปีที่แล้ว
Insilico Medicine's 6th Generation Intelligent Robotics Lab
Introducing Docuthon - A Documentary Hackathon for AI Drug Discovery
มุมมอง 1.2Kปีที่แล้ว
Introducing Docuthon - A Documentary Hackathon for AI Drug Discovery
Decoding Cancer with AI
มุมมอง 739ปีที่แล้ว
Decoding Cancer with AI
Jensen Huang, Co-founder, President and CEO of NVIDIA at Insilico Medicine’s Pharma.AI Launch
มุมมอง 2.1Kปีที่แล้ว
Jensen Huang, Co-founder, President and CEO of NVIDIA at Insilico Medicine’s Pharma.AI Launch
Pharma.AI Launch, November 14 2022
มุมมอง 1.3Kปีที่แล้ว
Pharma.AI Launch, November 14 2022

ความคิดเห็น

  • @geroldbendix1651
    @geroldbendix1651 2 วันที่ผ่านมา

    The Miller Urey experiment, linking chemical evolution with biology isn't holistic or complete at all. It's basically a very thin straw which so-called scientist cling to. Just by a few amino acids you will get not DNA or more basically nucleic acids, what to speak of a living, self-reproducing cell. The whole evolution theory lasts on this very thin basis .It's nothing more than wishful thinking. These fools are mad for recognition and fame and every year they celebrate themselves, thinking themselves to be most advanced, but actually they are just polished animals. Why? Because they don't give any credit to the most intelligent of all scientists, God himself.

  • @johnasonharris2853
    @johnasonharris2853 2 วันที่ผ่านมา

    I appreciate the fact that a Nobel Laureate acknowledged credits for discoveries might not be fairly due to people, because of various circumstances.

  • @Encrypted628
    @Encrypted628 3 วันที่ผ่านมา

    Loved it. Prof. made the lecture so easy to follow and understand. Excellent.

  • @niamcd6604
    @niamcd6604 25 วันที่ผ่านมา

    OMG, what a surprise. The NEVER-Nobel committee gave yet another prize to a white old Man😮😮😮 Please, putting that on the title is OLD, obsolete, and nowadays offensive too. That prize is just a mediocre celebration of white male supremacy. Many of whom stole their work from others. Not to mention they give thar to one person instead of teams. And oh, let's not forget that SEVERAL scientists whose skin is dark brown are TO THIS DAY completely ignored. PLEASE! Hide that thing in the title and save ot for other white supremacists who care about that instead of ethical scientific research.

  • @reggiepalmer6157
    @reggiepalmer6157 หลายเดือนก่อน

    Studying medicine and endocrinology for years as a bodybuilder, and graduating computer school in 1998. I dreamed of this happening and envisioned the future of medicine and health care finally being dominated by AI and ethical people. After witnessing with my own eyes in 1988 my girlfriend's mother get Cured of ovarian lymphatic and liver cancer stage 4. With a experimental drug from my girlfriend's Mother's roommate in college able to get medication through research and development from Dr BURZYNSKI. Only years later to watch the documentary BURZYNSKI the movie And to see just how scandalous and evil the FDA Drug companies and the medical community really is. Protect and bless all of you doing this great work.❤

  • @ganeshbhogaraju4558
    @ganeshbhogaraju4558 หลายเดือนก่อน

    I will be happy, if you could share us with few techno managerial aspects of realtime problems that you deal with in your day to day activities.

  • @EYE-EM-Actor-TNT-EMT-BMT
    @EYE-EM-Actor-TNT-EMT-BMT หลายเดือนก่อน

    Welcome to make branch in Bangladesh 🇧🇩

  • @davidmitchell3881
    @davidmitchell3881 หลายเดือนก่อน

    Fabulous case. Two thoughts. First could this be metastatic? Should he have a CT TAP? Second given that the inguinal lymph nodes are moderately enlarged perhaps an ultrasound might be useful. Ultrasound is better at identifing metastatic disease than CT for superficial lymph nodes. Biopsy might also be useful as the main lesion is tricky to biopsy

  • @bigal0172
    @bigal0172 หลายเดือนก่อน

    "Importantly, this success showed a massive milestone for our team and the broader generative AI field: from novel target discovery to Phase 1 testing in under 30 months. Relative to traditional drug discovery methodology, this AI-powered approach accomplished this feat in half the time and for a fraction of the cost." Amazing work! A true testament of the power of Generative AI.

  • @devyanipawar287
    @devyanipawar287 หลายเดือนก่อน

    Excellent !

  • @RajatThomas
    @RajatThomas หลายเดือนก่อน

    Super exciting! Keep up the great work.

  • @muninagarwala1987
    @muninagarwala1987 2 หลายเดือนก่อน

    Plz let me go there... I will not disappoint you.. I am very focused and dedicated...

  • @geeseylynn
    @geeseylynn 2 หลายเดือนก่อน

    SEE PEOPLE! THIS IS THE CRAP! BOGUS! NARCISSISTIC! DO NOT FOLLOW THESE CRAZY PEOPLE!

  • @dipiti8739
    @dipiti8739 2 หลายเดือนก่อน

    AI will be badly misused to make lots and lots of garbage.

  • @tinacole1450
    @tinacole1450 2 หลายเดือนก่อน

    do you all utilize knime or know of any program which utilizing this tool in drug discovery ? I am trying to understand how to do similarity with it.

    • @niamcd6604
      @niamcd6604 25 วันที่ผ่านมา

      Forget about getting an answer, if our skin isn't bleached to white walls levels, they don't even see us.

  • @amirpy5426
    @amirpy5426 2 หลายเดือนก่อน

    Nice one, how about your plan for IPO? Any investment from Nvidia?

  • @SBalajii
    @SBalajii 3 หลายเดือนก่อน

    this is great work! where can I learn more about timelines and ongoing trials?

  • @SAWARNCONCEPTpharmacy
    @SAWARNCONCEPTpharmacy 3 หลายเดือนก่อน

    In the current status of Indian women people suffering from cervical cancer, Dear, insilco medicine please immediately prepare (manufacturing) cervical cancer drug for kill subatomic levels of cancer cells using AI techniques..... Thanku

  • @cityplanconsultores2188
    @cityplanconsultores2188 3 หลายเดือนก่อน

    cool

  • @AbiramiM-hu9tj
    @AbiramiM-hu9tj 4 หลายเดือนก่อน

    What is the cost of inclinico

  • @sohanroking
    @sohanroking 4 หลายเดือนก่อน

    Hi any course available about drug design course I am related to chemistry field

    • @niamcd6604
      @niamcd6604 25 วันที่ผ่านมา

      Keep dreaming. These large fake inflated egos are NOT here for science but to mentally m@sturb#te every time someone pretends to be impressed with their 'work'. Which most of the time is RESULT OF ACTUALLY LARGE TEAMS, and several other times STOLEN FROM STUDENTS.

  • @EZTechTraining
    @EZTechTraining 4 หลายเดือนก่อน

    🎯 Key Takeaways for quick navigation: 01:08 🩸 *Blood pressure measurement on a smartwatch, like Omron's, is heavy and cumbersome, resulting in a bad experience (Tier E).* 01:49 🩸 *Measuring blood pressure on the upper arm is smooth, comfortable, and widely known, offering a great experience (Tier A).* 02:30 🩸 *Measuring blood pressure on the wrist, like with Lokavok, is similar to upper arm cuffs but smaller, falling into the "fine" category (Tier B).* 03:00 🍷 *Measuring blood alcohol content with digital devices can be fun and useful in countries with zero tolerance policies (Tier A).* 03:29 🍴 *Smart utensils like vibrating forks can teach users to eat slowly and change their behavior, resulting in a "fine" experience (Tier B).* 03:54 🌡️ *Measuring body temperature with a dedicated digital device can be useful but may seem redundant when integrated into other devices (Tier C).* 04:23 ❤️ *Measuring heart rate with smartwatches is a useful and effortless experience, categorized as "superb" (Tier S).* 04:51 🏋️ *Fitness tracking with various devices can be challenging to find the right fit but offers a smooth and great experience once chosen (Tier A).* 05:17 🛏️ *Measuring sleep quality under the mattress elevates the data but is not as essential as Smartwatch data, categorized as "fine" (Tier B).* 05:45 🛌 *Sleep quality headbands are an uncomfortable experience, earning an "awful" rating (Tier E).* 06:12 💤 *Measuring blood oxygen levels with dedicated devices is considered useless when most smartwatches can do the same, resulting in a "bad" experience (Tier D).* 06:52 ⏰ *Smart sleep alarms integrated into smartwatches are highly praised and deemed the most crucial feature for lifestyle improvement, rated as "superb" (Tier S).* 07:21 📈 *Measuring ECG on a smartwatch is convenient and helpful, falling under the "great" category (Tier A).* 07:48 💓 *ECG measurement on the chest with 24-hour devices provides accurate data, resulting in a "superb" experience (Tier S).* 08:18 🧡 *ECG measurement with your hands using devices like Cardia offers a superb experience, validated in clinical studies (Tier S).* 08:58 🧠 *Measuring EEG with a headband helps with meditation and mental health but is a tricky experience, leaning towards "meh" (Tier C).* 09:26 🤯 *Measuring stress with dedicated devices is considered unhelpful, especially when many smartwatches and apps offer stress tracking, resulting in a "bad" rating (Tier D).* 10:08 👀 *Measuring vision with devices like the IQ offers an extraordinary experience, being cheap, useful, and suitable for widespread use (Tier S).* 10:36 🩸 *Measuring blood glucose with skin patches is potential but comes with some discomfort and limitations, rated as "fine" (Tier B).* 11:59 👂 *Ear health devices like the HearScope allow users to check their inner ear health, providing useful data for physicians, categorized as "great" (Tier A).* 12:54 💨 *Measuring lung capacity, such as with the Smart Peak Flow for asthma management, offers a fine experience, despite some limitations (Tier B).* Made with HARPA AI

  • @AbellLincoln
    @AbellLincoln 4 หลายเดือนก่อน

    God Gave Noah the Rainbow Sign No More Water but Fire Next Time 🌈🙏🔥📡🌎🎶💥🤵👰❤️‍🔥🤴👸

  • @missisipi9992
    @missisipi9992 5 หลายเดือนก่อน

    Спасибо вам Алекс, такая деятельность крайне нужна, медицина и фарма в плачевном состоянии

  • @marcarianlawfirm5926
    @marcarianlawfirm5926 5 หลายเดือนก่อน

    Find the Right Attorney for Your Case Can Seem Impossible. If you or someone you know has been seriously injured by the negligence of another person, or if you are facing a pharmacy law or medical malpractice lawyer, you need to speak to an attorney today. At the Marcarian Law Firm, we are ready to investigate your case today.

  • @gertykitchenbrand9569
    @gertykitchenbrand9569 5 หลายเดือนก่อน

    This is EVIL ON STEROIDS....CONTROLLED BY THE CABAL........GOD CREATED US TO NEVER NEED ANY DRUGS...

  • @akafrancais2182
    @akafrancais2182 6 หลายเดือนก่อน

    Вау

  • @SamuelOseiAsokwah
    @SamuelOseiAsokwah 6 หลายเดือนก่อน

    I’m really interested in your works.. Thanks for the videos

  • @TolgaOzisik
    @TolgaOzisik 6 หลายเดือนก่อน

    which model are these robot arms

  • @atrium2528
    @atrium2528 6 หลายเดือนก่อน

    Well, that's interesting.

  • @chesterman18g
    @chesterman18g 6 หลายเดือนก่อน

    what did I just watch....

  • @josephvanname3377
    @josephvanname3377 6 หลายเดือนก่อน

    reversible computing

  • @CreeperLP81
    @CreeperLP81 6 หลายเดือนก่อน

    That looks awesome but why does it feel like a stop motion movie ?

  • @punishedfoxo
    @punishedfoxo 6 หลายเดือนก่อน

    Not an e-stop in sight 😬

  • @user-ij4rz3jz7b
    @user-ij4rz3jz7b 6 หลายเดือนก่อน

    ❤praise God 🐕 thank you Jesus Christ for being our savior ❤

  • @metamind095
    @metamind095 7 หลายเดือนก่อน

    Amazing setup you ve there! Please find a better analog to tabernanthalog that is derived from ibogaine...that has GDNF enhancing properties. Wish you all the best.

  • @georgejetson2637
    @georgejetson2637 7 หลายเดือนก่อน

    Took our juuurbs😂😂😂

  • @merlynraber3308
    @merlynraber3308 7 หลายเดือนก่อน

    When will the new dug be available?

  • @kinngrimm
    @kinngrimm 7 หลายเดือนก่อน

    I am rather sceptical on the claim that AI would democratize anything, especially aslong they are owned and controllled by corporations. In a worst case scenario the opposite may become true as in part we see it in China and the USA where their gigantic survialance capabilities can be used in ways not conform to democratic principles either directly on their own population or indirectly on the population of other nations where it somehow then becomes ok. Medicly used AI may not be an exception there either.

  • @ALFTHADRADDAD
    @ALFTHADRADDAD 8 หลายเดือนก่อน

    Tight

  • @alif_saiyyed
    @alif_saiyyed 8 หลายเดือนก่อน

    Starts at 4.30

  • @SilverFan21k
    @SilverFan21k 8 หลายเดือนก่อน

    Ha cool video

  • @Dan-xl8jv
    @Dan-xl8jv 8 หลายเดือนก่อน

    Excellent presentation. Really gives a holistic overview of the field and the way alpha fold can’t achieve what it did without standing on the shoulder of past sixty years of work in producing the examples and data.

  • @BitsOfQuantum
    @BitsOfQuantum 8 หลายเดือนก่อน

    That's great you work in drug discovery: thank you for your contributions. As you know better than me, drugs are temperature sensitive; how do you feel about big pharma shipping there medications in uncontrolled containers? For example, a chemotherapy pill which states not to exceed a certain temp.

    • @murkje
      @murkje 7 หลายเดือนก่อน

      what a great question, just here incase you get an answer

  • @Telencephelon
    @Telencephelon 8 หลายเดือนก่อน

    360p. That's advanced

  • @curingaging
    @curingaging 8 หลายเดือนก่อน

    excited to be there!

  • @surfreadjumpsleep
    @surfreadjumpsleep 8 หลายเดือนก่อน

    can we watch online while it happens or will it be released slowly over the year like prior years?

  • @surfreadjumpsleep
    @surfreadjumpsleep 8 หลายเดือนก่อน

    excited about AI working on science.

  • @user-ih2tt4ji6g
    @user-ih2tt4ji6g 9 หลายเดือนก่อน

    I am interested in drug discovery in computer design please.

  • @RitaArrigo
    @RitaArrigo 9 หลายเดือนก่อน

    Loved the Idea of an AI for A Human, The digital twin of the Human Body