Michael Fralick
Michael Fralick
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SGLT2i: Everything you need to know in 5 minutes
www.sglt2rx.com/
www.glp1-rx.com/
References
[1] www.nejm.org/doi/full/10.1056/NEJMoa1504720
[2] www.nejm.org/doi/full/10.1056/NEJMoa2107038
[3] www.nejm.org/doi/full/10.1056/NEJMoa2022190
[4] www.nejm.org/doi/full/10.1056/NEJMoa2107038
มุมมอง: 151

วีดีโอ

Ozempic (semaglutide): Everything you need to know in 5 minutes
มุมมอง 11414 วันที่ผ่านมา
www.glp1-rx.com/ fralicklab.com References www.nejm.org/doi/full/10.1056/NEJMoa2403347 www.nejm.org/doi/full/10.1056/NEJMoa2306963 www.nejm.org/doi/full/10.1056/NEJMoa2307563 www.nejm.org/doi/full/10.1056/NEJMoa1607141
Confounding: Everything you need to know in 5 minutes!
มุมมอง 104หลายเดือนก่อน
Brought to you by www.fralicklab.com Check out jrnowl.com to stop wasting your time when trying to find journal submission requirements! Higher level teaching point: Confounder is a common cause* of the exposure and outcome and not on the causal pathway. *Markers of a common cause also fall in that bucket. For age to be a confounder it does not have to cause anything but it is a marker for othe...
Stats 101 for med students: everything you need to know in 7 minutes
มุมมอง 2062 หลายเดือนก่อน
95% CI: everything you need to know in 5min - th-cam.com/video/5eAGXsY9LSI/w-d-xo.html p values: everything you need to know in 5 min - th-cam.com/video/jZdMYUT1R6Y/w-d-xo.html Jrnowl.com - a free resource to waste less time when you are submitting manuscripts for publication tinystats.github.io/teacups-giraffes-and-statistics/index.html Thank you to Katarina Zorcic (Queen's University medical ...
Bias: everything you need to know in 5 min!
มุมมอง 2755 หลายเดือนก่อน
Brief video to introduce and define bias. Past videos include: - 95% confidence interval: th-cam.com/video/5eAGXsY9LSI/w-d-xo.html - p values: th-cam.com/video/jZdMYUT1R6Y/w-d-xo.html - RCTs: th-cam.com/video/cfymxVWy8YY/w-d-xo.html www.jrnowl.com/ Follow on twitter - @fralickmike
Tight vs liberal glycemic control: 3min summary
มุมมอง 726 หลายเดือนก่อน
www.nejm.org/doi/full/10.1056/NEJMoa2304855 cardiotrialfiles.substack.com/
Intro to 95% confidence intervals: 6 min crash course
มุมมอง 1K6 หลายเดือนก่อน
[1] Great resource here: tinystats.github.io/teacups-giraffes-and-statistics/index.html [2] www.jrnowl.com follow along on twitter @fralickmike
Lecture: crash course from pragmatic to adaptive RCTs
มุมมอง 1548 หลายเดือนก่อน
Here is the unabridged version of a lecture I gave on October of 2023 at Mount Sinai Hospital in Toronto, Ontario. www.jrnowl.com trialfiles.substack.com/ fralicklab.com/
P values: everything you need to know in 5 min
มุมมอง 1.3K9 หลายเดือนก่อน
Jrnowl.com - a free resource to waste less time when you are submitting manuscripts for publication NEJM Evidence stats stat - th-cam.com/video/85lLfUHmmYQ/w-d-xo.html&ab_channel=NEJMGroup Episheets - www.rtihs.org/episheet
3 min RCT: once weekly insulin!!
มุมมอง 4909 หลายเดือนก่อน
Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/ www.nejm.org/doi/full/10.1056/NEJMoa2303208
RCT in 3min: SGLT2s improve hemoglobin in CKD!
มุมมอง 18510 หลายเดือนก่อน
Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/ evidence.nejm.org/doi/full/10.1056/EVIDoa2300049
Thrombocytopenia - everything you need to know in 3min
มุมมอง 22811 หลายเดือนก่อน
This is a brief 3min crash course on thrombocytopenia meant for medical trainees and generalists (e.g., internists, family doctors). fralicklab.com/
Preventing critically low hemoglobin: 3minute overview
มุมมอง 10711 หลายเดือนก่อน
This video is intended for staff and trainees at St Michael's hospital in Toronto to provide a primer on a new decision support tool. The tool aims to decrease the number of blood transfusions and critically low hemoglobin values
RCT in 3min: Goals of Care Conversations
มุมมอง 8711 หลายเดือนก่อน
Link to article: jamanetwork.com/journals/jama/fullarticle/2805346 Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/
So you want to start an RCT: everything you need to know in 16min
มุมมอง 234ปีที่แล้ว
I hope this will give people a sense of what is needed before running their own randomized trial. For more resources you can checkout fralicklab.com and jrnowl.com
NG tubes - everything you need to know in 5 minutes
มุมมอง 168ปีที่แล้ว
NG tubes - everything you need to know in 5 minutes
RCT in 3min: CLEAR trial of bempedoic acid
มุมมอง 266ปีที่แล้ว
RCT in 3min: CLEAR trial of bempedoic acid
3min RCT: RSV vaccine for older adults!
มุมมอง 117ปีที่แล้ว
3min RCT: RSV vaccine for older adults!
RCT in 3min: Hydrocortisone in Severe CommunityAcquired Pneumonia
มุมมอง 1Kปีที่แล้ว
RCT in 3min: Hydrocortisone in Severe CommunityAcquired Pneumonia
3 min RCT: IRONMAN - IV iron for heart failure
มุมมอง 339ปีที่แล้ว
3 min RCT: IRONMAN - IV iron for heart failure
ECG crash course in 7min for nurses and medical students
มุมมอง 1.3Kปีที่แล้ว
ECG crash course in 7min for nurses and medical students
A crash course on types of RCTs: Everything you need to know in 6min!
มุมมอง 638ปีที่แล้ว
A crash course on types of RCTs: Everything you need to know in 6min!
3 min RCT: NOSTONE Trial HCTZ for recurrent kidney stones
มุมมอง 309ปีที่แล้ว
3 min RCT: NOSTONE Trial HCTZ for recurrent kidney stones
3min RCT: DELIVER Trial
มุมมอง 273ปีที่แล้ว
3min RCT: DELIVER Trial
Anemia crash course: everything you need to know in 3min
มุมมอง 569ปีที่แล้ว
Anemia crash course: everything you need to know in 3min
Run in phases for clinical trials: everything you need to know in 2min
มุมมอง 695ปีที่แล้ว
Run in phases for clinical trials: everything you need to know in 2min
3min RCT: CLASSIC trial
มุมมอง 145ปีที่แล้ว
3min RCT: CLASSIC trial
3min RCT: Psilocybin for depression
มุมมอง 120ปีที่แล้ว
3min RCT: Psilocybin for depression
3min RCT: chlorthalidone vs hctz
มุมมอง 604ปีที่แล้ว
3min RCT: chlorthalidone vs hctz
Resume / CV Tips for resident physicians
มุมมอง 801ปีที่แล้ว
Resume / CV Tips for resident physicians

ความคิดเห็น

  • @heenajariyal6620
    @heenajariyal6620 21 ชั่วโมงที่ผ่านมา

    Tirzepatide from Eli Lilly

  • @nesrinaa4844
    @nesrinaa4844 29 วันที่ผ่านมา

    THANK YOU

  • @gazoline4070
    @gazoline4070 หลายเดือนก่อน

    This is a very good alternative to statin. Statin feels like someone smashed your head. This feels a thousand times better

  • @danielaperezvasquez3340
    @danielaperezvasquez3340 หลายเดือนก่อน

    Omg!! This was perfect thanks!

  • @jananys3156
    @jananys3156 หลายเดือนก่อน

    thank you so much for this video helped me with my journal club!

  • @ghadah9120
    @ghadah9120 2 หลายเดือนก่อน

    Michael, the man that you’re!! Thank you from the bottom of my heart.

  • @frankpeprah6198
    @frankpeprah6198 2 หลายเดือนก่อน

    Very informative

  • @josephinechikapa9587
    @josephinechikapa9587 2 หลายเดือนก่อน

    Thank you for this lecture it is really helpful

  • @FROSTHAWK247
    @FROSTHAWK247 3 หลายเดือนก่อน

    I am a masters student studying social work and even when the focus of the research is different the process of calculating these scores is more or less similar. This video was a great deal of help and extremely digestible, thank you so much!

    • @Fralickmike
      @Fralickmike 3 หลายเดือนก่อน

      That’s very kind of you. And I’m glad you found it helpful !

  • @frankvanschellen4980
    @frankvanschellen4980 3 หลายเดือนก่อน

    thank you for this great explanation! Is there also a possibility when having 3 treatment groups to calculate propensity scores with the same strategy?

    • @Fralickmike
      @Fralickmike 3 หลายเดือนก่อน

      You’re most welcome. There is but that gets complicated fast! If there are 3 groups and one is the ref then I do two pair wise comparisons to the ref. Hope that helps.

  • @dr.tomadragos-medicreziden1806
    @dr.tomadragos-medicreziden1806 3 หลายเดือนก่อน

    DB RCT are the best! Thank you for the content! Why should i listen to other trials if they are vulnerable to biases?

    • @Fralickmike
      @Fralickmike 3 หลายเดือนก่อน

      Sometimes double blind trials is not feasible and sometimes not possible. also, unblinded RCTs are still very useful. but they are just prone to some biases that double blinded trials are not

  • @josefoso15
    @josefoso15 3 หลายเดือนก่อน

    Fantastic! Nicest explanation of PSM ever

    • @Fralickmike
      @Fralickmike 3 หลายเดือนก่อน

      Thx so much!

  • @akshitbhalla874
    @akshitbhalla874 4 หลายเดือนก่อน

    Thank you so much for making this video!

    • @Fralickmike
      @Fralickmike 4 หลายเดือนก่อน

      My pleasure. Thank you for your kind words!!

  • @augustinechukwunta680
    @augustinechukwunta680 4 หลายเดือนก่อน

    Great video - well explained

  • @augustinechukwunta680
    @augustinechukwunta680 4 หลายเดือนก่อน

    Great video - you made it so easy to understand

    • @Fralickmike
      @Fralickmike 4 หลายเดือนก่อน

      thank you very much!!

  • @osashruf
    @osashruf 4 หลายเดือนก่อน

    Great vid! Would love to see a crash course on Kaplan-Meier/survival analysis

    • @Fralickmike
      @Fralickmike 4 หลายเดือนก่อน

      Great idea. Will work on that one in the future for sure

  • @yoshtisune
    @yoshtisune 5 หลายเดือนก่อน

    Can you talk about confidence intervals in depth? I’m having a hard time trying to interpret it

    • @Fralickmike
      @Fralickmike 5 หลายเดือนก่อน

      Yes here is recent video on it. th-cam.com/video/5eAGXsY9LSI/w-d-xo.htmlsi=58K48FXROpUEm4is

  • @stanislavlegkovoy2119
    @stanislavlegkovoy2119 5 หลายเดือนก่อน

    thanks, pretty clear

  • @svenkreutzer5617
    @svenkreutzer5617 5 หลายเดือนก่อน

    Great, thanks!

  • @silverlight7938
    @silverlight7938 5 หลายเดือนก่อน

    Really helpful, I wanted to ask What is the difference between Propensity score matching and Case control matching (SPSS)?

    • @Fralickmike
      @Fralickmike 5 หลายเดือนก่อน

      Case control matching is unrelated. Here is great resource on everything you need to know about case control studies sphweb.bumc.bu.edu/otlt/MPH-Modules/EP/EP713_Case-Control/

  • @user-uu7co5li9v
    @user-uu7co5li9v 5 หลายเดือนก่อน

    Thanks for the clear explanation!

    • @Fralickmike
      @Fralickmike 5 หลายเดือนก่อน

      My pleasure. Thank you for watching

  • @flori2611
    @flori2611 6 หลายเดือนก่อน

    THANK YOU SO MUCH

    • @Fralickmike
      @Fralickmike 6 หลายเดือนก่อน

      My pleasure. I’m happy you enjoyed it

  • @ericyeh4315
    @ericyeh4315 6 หลายเดือนก่อน

    genius! deeply appreciate this video! helpful for med students drowned by statistical terms

    • @Fralickmike
      @Fralickmike 6 หลายเดือนก่อน

      Thank you !

  • @A_Psych_Nurse
    @A_Psych_Nurse 6 หลายเดือนก่อน

    Hi Michael, Appreciate this breakdown, despite most of it going over my head. When you say these statistical methods do not mimic RCTs, what exactly does that mean? How closely do we get to the results of a RCT using this method, and has this method been verified against the findings of RCTs? The reason I'm asking this is b/c I came across a cohort article comparing adolescents who took antipsychotic medication vs. those who didn't, and compared how they were doing 5 years later. The article suggests, after using IPTW, that antipsychotic medication in those w/ their first episode of psychosis, actually makes for a worse 5 year outcome. I'm skeptical though b/c it's a cohort study and no randomization was done. The authors acknowledge this weakness, and then state that the Stabilized IPTW is used to eliminate the possibility that those with worse psychosis were the ones who were given an antipsychotic medication. (I think this is the most probable explanation for why those who were given AP medication fared worse. . .simply b/c they already were experiencing more profound psychosis and so we would expect them to be doing worse at a 5 year follow-up). Seems super fishy to me. . .any thoughts here are appreciated, thx.

    • @Fralickmike
      @Fralickmike 6 หลายเดือนก่อน

      You are totally right to be skeptical. There’s no way to answer this Q “how close do we get to the results of a RCT”. It would be like asking how much does this glass of wine taste like a beer. They are two different things. To learn more about why RCTs are so powerful and what randomization achieves (that no cohort study can) here is link to my 6min crash course on RCTs: th-cam.com/video/oQt8jR5RgVQ/w-d-xo.htmlsi=cpMn3c6YQnWYj3wv

    • @A_Psych_Nurse
      @A_Psych_Nurse 6 หลายเดือนก่อน

      awesome, thank you for the insanely prompt and helpful response Michael!@@Fralickmike

  • @yutingchen9701
    @yutingchen9701 6 หลายเดือนก่อน

    great video!

    • @Fralickmike
      @Fralickmike 6 หลายเดือนก่อน

      Thank you!!

  • @ishikahalder799
    @ishikahalder799 6 หลายเดือนก่อน

    🤩

  • @user-oj2bu6sv3n
    @user-oj2bu6sv3n 7 หลายเดือนก่อน

    Very good lesson except that you are extremely fast. I wish you could slow down your pace

    • @Fralickmike
      @Fralickmike 7 หลายเดือนก่อน

      Thank you for feedback. Note you can slow the speed to 0.75 or 0.5 to slow it down

  • @ajkovic914
    @ajkovic914 8 หลายเดือนก่อน

    Thank you so much. Plz make more videos especially about meta-analysis

    • @Fralickmike
      @Fralickmike 8 หลายเดือนก่อน

      Thank you for your kind words!!

  • @jamesharte8390
    @jamesharte8390 8 หลายเดือนก่อน

    excellent breakdown and synopsis. Thank you.

  • @girlthatcooks4079
    @girlthatcooks4079 8 หลายเดือนก่อน

    There are 3 scores as 0.6, would it be fair/unbiased to match with random 2 only?

    • @Fralickmike
      @Fralickmike 8 หลายเดือนก่อน

      that is a good question. you are right that it would be ok to pick at random. In some studies people match "many to one". so you could keep all 3. But the "ideal" approach is 1:1 based on prior studies.

    • @girlthatcooks4079
      @girlthatcooks4079 8 หลายเดือนก่อน

      @@Fralickmike Thank you!!

  • @ruiz_aeg
    @ruiz_aeg 8 หลายเดือนก่อน

    I learnt so much. Such a good presenter. Thank you!

    • @Fralickmike
      @Fralickmike 8 หลายเดือนก่อน

      Thank you! That’s very kind of you

  • @articulatepro4449
    @articulatepro4449 8 หลายเดือนก่อน

    This lecture coul even solve a particular question... kept rigmaroles coming...

  • @taifshah9003
    @taifshah9003 8 หลายเดือนก่อน

    you are so stupid, while giving a lecture, avoid your shit chatting with people

  • @datadoctor10
    @datadoctor10 9 หลายเดือนก่อน

    Thanks for the video

  • @yuyangzhu6822
    @yuyangzhu6822 10 หลายเดือนก่อน

    Thank you for the video!! saved me when I got totally lost in my intermediate pharmacoepidemiology class 😂

  • @sushiman972
    @sushiman972 10 หลายเดือนก่อน

    Doing an analysis on a controlled trial you were involved in just feels like cheating. But super helpful video, Thank you!

  • @DrogbaPT454
    @DrogbaPT454 11 หลายเดือนก่อน

    Great summary. I think the only point that I would have added on patient baseline was highlighting the fatc that all patients were statin intolerant (and they signed a informed consent)

  • @MA-dd9dd
    @MA-dd9dd 11 หลายเดือนก่อน

    Thank you for uploading

  • @ivytruong4997
    @ivytruong4997 ปีที่แล้ว

    how do you set the 20% margin on the forest plot?

  • @rajmacwan665
    @rajmacwan665 ปีที่แล้ว

    Thank you Dr. Fralick for this video!! Can you please post your talk about everything you need to know about statistics ? Thanks again

    • @Fralickmike
      @Fralickmike ปีที่แล้ว

      Yes you are right that is a long overdue talk. I will work on it next

  • @addisalemtsegaye1271
    @addisalemtsegaye1271 ปีที่แล้ว

    Thank you

  • @ec.juanfranulcuangolee3294
    @ec.juanfranulcuangolee3294 ปีที่แล้ว

    Thank you dear teacher. Excellent, in spite of it wasn't in Spanish or without subtitles

  • @marjorieaijeelucero1149
    @marjorieaijeelucero1149 ปีที่แล้ว

    I cannot emphasize how helpful this lecture is. Thank you for making this available. Topics like these are very hard for me to understand on live face-to-face/online lectures. I need to pause a bit, rewind a bit to catch the concepts. THANK YOU!

    • @Fralickmike
      @Fralickmike ปีที่แล้ว

      Thanks that’s very kind of you!!

  • @chadibenchakroun6465
    @chadibenchakroun6465 ปีที่แล้ว

    Can you please explain the slide at 5:10? Why don't we have the same number of persons, means...? Is it just that we do not take into account people without a match?

  • @user-yw1ul4xq1g
    @user-yw1ul4xq1g ปีที่แล้ว

    Very helpful video for rookies like me😊

  • @TheVishu27
    @TheVishu27 ปีที่แล้ว

    One of the best 👍💯

  • @khadeijahussain6000
    @khadeijahussain6000 ปีที่แล้ว

    Great lecture Michael! can anyone help me understand how to use the Newcastle Ottawa scale a little better? The questionnaire seems pretty straightforward but I'm not sure if I am interpreting it correctly.

  • @hpthelegend
    @hpthelegend ปีที่แล้ว

    Very informative video😊 I will suggest the channel to my colleagues too

    • @Fralickmike
      @Fralickmike ปีที่แล้ว

      thank you!!

    • @georgestone6807
      @georgestone6807 ปีที่แล้ว

      Can u make a video how to critical analyze clinical trials , the interpretation is so varied Will appreciate that

  • @alsonyang230
    @alsonyang230 ปีที่แล้ว

    Thank for the concise videos that explain the overall concept very well. It was very easy to understand. There are 3 implementation details during the matching phase (at 5:00) hoping you could clarify. 1. After we get the score, if there are two rows with scores 0.5 in control group (where `SGLT2 = No`), should both of them be matched to row 3 in treatment group? 2. In the real world, the score would rarely be exactly the same if we allow infinite decimal. How do you consider a match? Would there be an arbitrary numeric difference allowed? 3. If there are two rows in treatment with score 9.15 and 9.18 (row A and B), and two rows in control with score 9.16 and 9.25 (row C and D). Would row A and B both be matched to C? Or would row A matched to C as they are have the smallest difference, then row B has to be matched to D?

    • @Fralickmike
      @Fralickmike ปีที่แล้ว

      The stats section of this article will help answer your Qs www.acpjournals.org/doi/10.7326/M19-2610

  • @Lozion90
    @Lozion90 ปีที่แล้ว

    Hi Dr. Fralick, thank you for this video. Is there a rapid way to remove duplicates from the whole sample of selected articles?

    • @Fralickmike
      @Fralickmike ปีที่แล้ว

      Yes! The program COVIDENCE does this