The BIOne benchtop scale single-use bioreactor (SUB) is for mammalian cell growth, cell therapy, insect cells, and other unique applications performed in a stirred tank bioreactor. The gamma irradiated BIOne SUB is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a disposable SUB within a matter of seconds. Upon media addition, the liner expands and molds to the glass vessel, preserving the geometry of the existing bioreactor.
The BIOne SUB’s liner material emulates the large-scale SUBs used in pilot and commercial biopharma production facilities around the world. Performing R & D studies using the most similar material on the market streamlines your tech transfer and can de-risk your process BEFORE transferring to pilot scale.
Customizable above & below the Headplate -
2L / 5L / 10L Working Volume
Optional Single-Use pH Probe
Increased Throughput
Weldable Tubing
Flute, Micro & Open Pipe Sparging Options
Non-Invasive DO & Optional pH Probe Ports
USP Class VI Materials
Repligen® ATF Perfusion Tube Compatible
Animal Derivative-Free
Low Antioxidant Liner Material
Compatible with Most Manufacturers’ Glass Vessels and Controllers
DO & pH Probe Ports -
Non-Invasive (Amperometric DO/Optical pH)
PG-13.5 (Optical DO/Electrochemical pH)
Optional Integrated Single-Use pH Probe
Pitched Blade Impeller - Single or Dual Impeller
Sparging Options -
Flute Sparger (7 x 1.5 mm hole)
Micro Sparger (20-40 µm pore size)
Open Pipe Sparger (1 x 3.0 mm)
Low Antioxidant Liner Material -
Outer Layer (LDPE) - Mechanical Strength
Middle Barrier Layer (EVOH) - Gas Barrier
Contact Layer (ULDPE) - Cell Culture Compatible, Biologically Inert