Nana Kwame Ampadu (31 March 1945 - 28 September 2021) was a Ghanaian musician credited with numerous popular highlife tracks and he is known to have composed over 800 songs.

Ampadu's "African Brothers Band" was formed in 1963. One of the founding members was Eddie Donkor. He came to prominence in 1967 when he released his song Ebi Te Yie (or "Some Are Well Seated"), a song that was seen as potentially critical of the then-governing National Liberation Council and disappeared from the airwaves, only returning after the end of military rule.

In 1973 he won a nationwide competition in Ghana to be crowned the Odwontofoohene, or "Singer-in-Chief".
During the '70s, they became one of the more innovative bands on the scene, as they experimented with influences from other areas, including the rumba, reggae, and a form of music meant to incorporate all of the African forms, Afro-hili, which was also made as a competitor to Fela Kuti's Afrobeat. After some time, they have returned to a purer form of guitar highlife, though hundreds of albums (mostly in Ghana) can attest to their longevity and creativity.