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For me, antivirals did nothing for long covid. I had a functional medicine doctor who prescribed 15 days of an antiviral. I have also been diagnosed with chronic lyme, reactivated Epstein Barr, and ME/ CFS. I think the research doctors need to think more in the way of immune modulators. Look at AIDS patients. They now have medication that make them live a longer life. I'm just a layman with a non-scientific opinion.

Thanks for sharing. My sense is that an immunomodulator plus an anti-viral may avail some success. Of course, there might be some mitigating factors such as side effects. Thanks for sharing. 460 pages - eeesh! Good luck - hang in there.

I was waiting for the Numbers needed to treat

Mecfs , long COVID are real

I have several family members taking Nexlizet with zero side-effects.$40 copay. The PCSK9 injections cost more for insurance companies. Nexlizet will take market share from the PCSK9 market, currently an estimated 10 to 17 Million Americans are taking PCSK9 drugs. Nexlizet is estimated to used by 5 Million Americans by 2027 hence this will be a Block buster drug. Nexletol will could be prescribed to 4 to 7 Million Americans for Statin intolerance on the low end as a prevention within 3 to 5 years. Esperion Therapeutics will probably be bought out for it's pipeline soon.

I believe CHRONIC STRESS is one of the most important factors as to why people develop Long COVID, Chronic Fatigue Syndrome/ME, Fibromyalgia, Chronic Lyme Disease, MCAS, and POTS. Eliminating the Chronic Stress root cause is required for treatment and prevention of these diseases. If the Long COVID patient has reached the point where some movement is also possible, stretching , ight yoga, mild exercise, such as a walk in Nature, may help improve Sleep, further reducing Stress. The JUST ROB Channel offers Polyvagal exercises to calm the Nervous System and other unique information. Loss of a Loved One, Divorce, Loss of a Job/Financial Security, a Traumatic Accident or Childhood Event, Surgery, or Athletic Overtraining are all examples of Chronic Stress. But one of the WORST Chronic Stresses is if you Believe you will get Very Sick or Die from an illness. A Type-A High Achiever/Perfectionist Personality typically will place healthful activities, such as getting a proper night’s sleep, as secondary to accomplishments. Type A’s will often want to quickly resume work and exercise, rather than rest and fully recover. An acute infection, such as COVID-19, can be merely the Trigger to the complete breakdown of an ALREADY Compromised Immune System from Chronic Stress. Once the breakdown occurs, secondary infections of other viruses (such as Epstein-Barr Virus), bacteria, molds, protozoans, and parasites that were FORMERLY being held in remission will now resurface. There is also little innate Immune System response to stop any NEW infections. The exacerbation of the effects of Environmental Toxins, Autoimmune Diseases, Allergies, and other Comorbidities may further complicate the disease and make it unique to almost EVERY Long Hauler! 🙀 Chronic Stress suppresses the Immune System and Digestion, making it more likely to develop Immune System dysfunctions, such as MCAS, and poor absorption of essential nutrients, leading to deficiencies that can cause issues like Leaky Gut. A deficiency in B-Complex Vitamins can lead to Leaky Gut as well as a Leaky Blood/Brain Barrier. A leaky BBB will allow pathogens and foreign proteins into the Brain, where they may cause inflammation, leading to Dysautonomia, Brain Fog, Loss of Memory, Headache, Depression & Anxiety, Chronic Fatigue, and other neurological symptoms. A B Vitamin deficiency will also make you feel more Stressed, and the primary objective is to Reduce Stress. Deep Sleep is the ONLY Time the waste products of inflammation and normal metabolism are removed from the Brain, so reduction of Chronic Stress to allow a Good Night’s Sleep is important for treatment. Typically, a Change in Attitude is required to reduce Chronic Stress and disrupt the endless repetition of negative thoughts. LifeWithKyle discusses how he uses Meditation to Calm his Nervous System and diminish Long COVID symptoms during a relapse. He offers Guided Meditations that are designed to make one feel SAFE, reducing Stress and avoiding the “Fight or Flight” Immune response. Fasting is a good Lifestyle Change to help restore integrity to the Gut and Blood/Brain Barrier as well as repair a dysfunctional Immune System. It gives the intestines a rest from Digestion, allowing energy to be focused on Repair. Fasting is a Stress on the Body, and like Exercise, should be approached gradually, probably AFTER you’ve had success with Meditation and Breathwork. However, one should realize EVERYONE FASTS WHEN THEY SLEEP. The key is to extend the benefits of Fasting into your Waking Hours. You should start with Time-Restricted Eating, gradually reducing the time of your Daily Feeding Window until you are comfortable eating within an 8 hour or less Feeding Window. From there, you can attempt a 24 hour or Multi-Day Fast. Don’t be discouraged if you end a Fast early. You can try again on another Day. Fasting will be easier if you follow a Healthy Low Carb, Whole Food Ketogenic Diet. Dr. Eric Berg can show you how to begin. Eliminating Grains and consuming Nutritional Yeast, a great source of B-Complex Vitamins, along with other B Vitamin-rich foods and supplementing Vitamin B1, will help to restore Intestinal and Blood/Brain Barrier integrity.

Very informative. This video needs millions of views. Bempedoic Acid (Nexletol) clearly will be a block buster. Not many doctors know about it. Over 20% on MACE 4 and better results with more time taking the drug. Yearly drug cost per patient $4,200 and is a Tier 2 and now covered under most insurance at $40 copay. 18M Americans are maxed out on Statins and need combination drug, This should be the standard and probably see 5 million patients prescribed Nexletol that is $21 billion a year in sales revenue and would value Esperion (ESPR) at over $200 per share. Current stock price $1.39. Esperion has $1.5 billion in future milestone payments. Label expansion will be next in early 2024 and result in far greater prescriptions.