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MRC IEU at University of Bristol
เข้าร่วมเมื่อ 29 พ.ย. 2013
The MRC Integrative Epidemiology Unit at the University of Bristol (IEU) establishes an innovative collection of programmes and cross-cutting themes, underpinned by core research activities to fuel a step-change in causal analysis methods and their application. This channel collates videos of presentations and research activity by members of the IEU.
IEU Seminar: Siana Jones
Title: Physical activity in childhood and adolescence to promote cardiovascular health in adulthood
Abstract: Physical activity (PA), particularly exercise training, is beneficial for cardiovascular (CV) health but the long-term benefits of undertaking PA throughout childhood and adolescence on adult CV health are poorly understood. In this presentation I aim to describe the rationale, methods and pilot analyses from a recently submitted research proposal that incudes analyses using longitudinal PA data and CV health outcomes measured in G1 ALSPAC participants.
Biography: I am a Senior Post-doctoral Research Fellow at UCL in the MRC Unit of Lifelong Health and Ageing. I have a background in cardiovascular physiology and a specialist interest in the role skeletal muscle plays in cardiometabolic health. I have developed non-invasive methods for assessing skeletal muscle oxidative capacity and local muscle haemodynamic changes during exercise using optical imaging. I have applied these techniques in various studies to better understand skeletal muscle adaptations in health and disease.
Abstract: Physical activity (PA), particularly exercise training, is beneficial for cardiovascular (CV) health but the long-term benefits of undertaking PA throughout childhood and adolescence on adult CV health are poorly understood. In this presentation I aim to describe the rationale, methods and pilot analyses from a recently submitted research proposal that incudes analyses using longitudinal PA data and CV health outcomes measured in G1 ALSPAC participants.
Biography: I am a Senior Post-doctoral Research Fellow at UCL in the MRC Unit of Lifelong Health and Ageing. I have a background in cardiovascular physiology and a specialist interest in the role skeletal muscle plays in cardiometabolic health. I have developed non-invasive methods for assessing skeletal muscle oxidative capacity and local muscle haemodynamic changes during exercise using optical imaging. I have applied these techniques in various studies to better understand skeletal muscle adaptations in health and disease.
มุมมอง: 77
วีดีโอ
IEU seminar: Mary Schubauer-Berigan
มุมมอง 2014 วันที่ผ่านมา
Title: Evidence synthesis and integration for cancer hazard identification: the approach of the IARC Monographs programme Abstract: For over 50 years, the Monographs programme of the International Agency for Research on Cancer (IARC) has evaluated the carcinogenic hazard posed by more than 1000 agents, bringing together international expert working groups in cancer epidemiology, animal cancer b...
IEU Seminar: Andrew Mumford and Daniel Greene
มุมมอง 7214 วันที่ผ่านมา
Title: Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders. Abstract: The genetic aetiologies of more than half of rare diseases remain unknown. Standardized genome sequencing and phenotyping of large patient cohorts provide an opportunity for discovering the unknown etiologies. Here we demonstrate our computational approach to rare disea...
Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations
มุมมอง 10828 วันที่ผ่านมา
Prof George Davey Smith spoke on "Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations". He was giving the Sharwaree Gokhale Memorial Lecture at the Centre for Brain Research (CBR) Indian Institute of Science, Bangalore, India on 5th December 2023.
Fundamentals of Mendelian randomization in 2024
มุมมอง 2373 หลายเดือนก่อน
Professor George Davey Smith spoke at NTNU, Trondheim on 17th June 2024.
Everywhere and nowhere: will we ever identify the missing environmental causes of disease?
มุมมอง 5523 หลายเดือนก่อน
Professor George Davey Smith spoke at NTNU, Trondheim on 17th June 2024.
Introduction to Molecular drivers & predictors of pregnancy complications & future health programme
มุมมอง 1005 หลายเดือนก่อน
Deborah Lawlor and Caroline Borges give an introduction to the Molecular drivers & predictors of pregnancy complications & future health programme at the MRC Integrative Epidemiology Unit, University of Bristol. This programme undertakes translational research aimed at improving antenatal and postnatal care and inequalities in this care. For more information see: www.bristol.ac.uk/integrative-e...
Mendelian Randomization - what it was, what it is, and what it should become.
มุมมอง 6326 หลายเดือนก่อน
Recorded by UCL London on 25th April 2024.
Mendel’s randomness: from allowing complex life to facilitating causal inference
มุมมอง 1377 หลายเดือนก่อน
A talk by George Davey Smith at UCL on 13 February.
IEU Seminar: Vittal Katikireddi
มุมมอง 3527 หลายเดือนก่อน
Title: Developing evidence to address the economic determinants of health inequalities: Attempting to move from description to a policy response Abstract: The economic determinants of health are potentially of fundamental importance for population health and health inequalities. At the individual level, experiences of poverty, unemployment and financial insecurity have all been linked to poor h...
IEU Seminar: Matt Tudball
มุมมอง 5298 หลายเดือนก่อน
Title: Genetics-based drug discovery: Some stories from the frontline. Brief abstract: Human genetics has become an increasingly popular means of identifying modifiable therapeutic targets for disease. For the last 16 months, I have been working at a start-up that partners with biotech, venture capital and pharma companies to interrogate their drug candidates and identify new ones using human g...
ICEP research into cancer progression and novel treatments
มุมมอง 4710 หลายเดือนก่อน
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Philip Haycock of University of Bristol discusses the theme of cancer progression and novel treatments. This theme considers the most promising molecular targets for new and repurposed chemoprevention and therapeutic drugs.
IEU Invited Lecture: Michael Inouye
มุมมอง 24911 หลายเดือนก่อน
Title: Systems genomics for population health: From risk prediction to aetiology Brief abstract: Over the past 15 years, the generation of high-dimensional omics data in population research has become common place. In this talk, I’ll cover challenges and recent advances in using genomics, metabolomics, proteomics and other modalities for the purposes of disease risk prediction and understanding...
ICEP research on smoking cessation
มุมมอง 4311 หลายเดือนก่อน
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Jasmine Khouja of University of Bristol discusses the theme of smoking cessation. This theme looks at the causal effects of nicotine (including in e-cigarettes) on cancer risk and outcomes.
ICEP research into somatic genomics
มุมมอง 6911 หลายเดือนก่อน
Research in the Integrative Cancer Epidemiology Programme (bristol.ac.uk/icep) falls into six themes. In this video, Amy Francis of University of Bristol discusses the theme of somatic genomics. This theme looks at how exogeneous and endogenous factors influence the cancer-causing molecular aberrations that occur in body cells.
ICEP research into physical activity and sleep
มุมมอง 15711 หลายเดือนก่อน
ICEP research into physical activity and sleep
Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization - G. Davey Smith
มุมมอง 3Kปีที่แล้ว
Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization - G. Davey Smith
Taking the "neurodevelopmental" part of "neurodevelopmental disorders" - Kevin Mitchell
มุมมอง 564ปีที่แล้ว
Taking the "neurodevelopmental" part of "neurodevelopmental disorders" - Kevin Mitchell
From evolution at synonymous sites to improve gene therapy and diagnostics by Laurence Hurst
มุมมอง 152ปีที่แล้ว
From evolution at synonymous sites to improve gene therapy and diagnostics by Laurence Hurst
Using Mendelian Randomization to model the causal effect of cancer on health economic outcomes
มุมมอง 3.3Kปีที่แล้ว
Using Mendelian Randomization to model the causal effect of cancer on health economic outcomes
The changing paradigm in the pharmacological treatment of elevated blood pressure
มุมมอง 176ปีที่แล้ว
The changing paradigm in the pharmacological treatment of elevated blood pressure
Investigating the Development Origins of Health and Disease Using Statistical Genetics Methods
มุมมอง 211ปีที่แล้ว
Investigating the Development Origins of Health and Disease Using Statistical Genetics Methods
Trying to be a more useful epidemiologist: From heart disease to child maltreatment
มุมมอง 154ปีที่แล้ว
Trying to be a more useful epidemiologist: From heart disease to child maltreatment
Disputed inheritance: The battle over Mendel and the future of biology - Professor Gregory Radick
มุมมอง 628ปีที่แล้ว
Disputed inheritance: The battle over Mendel and the future of biology - Professor Gregory Radick
Integrative Cancer Epidemiology Programme (ICEP) Lab Tour
มุมมอง 398ปีที่แล้ว
Integrative Cancer Epidemiology Programme (ICEP) Lab Tour
Testosterone From This Life Toward Every Next Life Forever Within Physics And Or Metaphysics Forever Until The End Of Every Reality’s Existence Forever Factually > Estrogen
Thank you
nice talk!
What does residual vs ranked mean
Can PRS scores be used for MR
Why are genetic interventions more potent than pharmaceutical for cholesterol and hcy risk?
A great talk as always!
BRILLANT AND POWERFUL..
Once you learn Mendelian randomization, all the hottest chicks in the world are yours!
I’m worried about my baby developing autism because of anti depressants. To me it sounds like a no brainier. You shouldn’t be messing with the cerebral cortex of a developing baby. But this chick stated she was focusing on the miscarriage side of the side effects. Does anyone know or can recommend another talk that would have 30 yrs worth of evidence to help me out?? Thanx in advance
😳 *Promo sm*
Before Focke, in 1881, Mendel’s pea paper was cited four times (in 15 years since its publication); after Focke, not a single time. The so-called references are just catalog listings and mainly concern the hawkweed paper. De Vries’ reprint is no evidence for the “circulation of the 40 reprints”. Pea breeders like Rimpau and Giltay were unaware of Mendel’s work. Mendel’s contemporaries Wichura, Nägeli, and Caspary were cited many times. My conclusion: yes, Mendel’s work was neglected.
Mendel's work on peas was obscure and misunderstood before 1900. Most references were to his hawkweed hybrids or appeared in catalogs. Schmalhausen (1874) only found Mendel's pea paper when he already had his thesis at the printer and added an endnote. Focke (1882) also did not find Mendel until his book was almost finished. This shows that Mendel's pea work was little known. Schmalhausen wrote in Russian and Blomberg (1872) in Swedish, both internationally not widely spoken languages. Their publications were not rediscovered until well after 1900 and had no impact at their time. Hoffmann (1869) and Focke understood little of Mendel's pea paper. Four "real" references in almost 35 years is not a lot.
Rutherford notes that the great early opponent of eugenic sterilisation was G.K. Chesterton, but he doesn’t want to connect it too directly to Chesterton’s non-progressive, Catholic sanctity-of-life views; the same views which cause Catholics to oppose abortion. Rutherford supports abortion-on-demand. Yet today, the world’s single most extensive and successful eugenic program is the abortion of foetuses who test positive for Down’s Syndrome. In Europe, 92% of pregnant women who test positive choose to abort. High screening rates in Denmark and Iceland have resulted in there now being almost no one with Down’s Syndrome in either country.
🌹 "promo sm"
How exciting to see your HoloMonitor M4 live cell analysis system in action 😊 Greetings from your PHI team
Very insightful and incisive. These are long overdue needed reforms in statistical practice.
Wonderful
Great talk!
man i thought we were better than this, everyday i see the decay and devolution of humans to becoming controlled sheep slaves and incels, repeating garbage just like this. Question everything. Especially if theres a women talking about testosterone, and she is wrong, completely wrong. WE NEED STRONG MEN FOR FUCKS SAKE.
clicked off when i saw it was a WOMAN talking about testosterone and success
Yes, but we're just not that far back in human evolution. Phenotypic characteristics have been augmented by also behavioral observable characteristics, and performance observable characteristics, akin to human realm, that justify or refute the first. We do not need to re-discover anthropology, or reduce it to zoologia specialis, but naturally advance from that stand to anthropo-sociological natural selection parameters. If, then, that is already done, why discuss a subject leading to inferior, discriminatory, geno-puristic approaches?
It seems like she has an agenda against the theory that correlates testosterone to let's say successes. She is also complicating the matter by throwing the ' born with T Vs day circulating T." It doesn't matter to me were the T comes from. There is no doubt that T level and successes in men is correlated. It maybe bit exaggerated but there is a correlation. Instead of dismissing the link, the focus should be why certain men suffer from low T and how to remedy this. In the modern 'science' there is a lot of energy in dismissing certain realities to somehow ' comfort' those who lack these said attributes. I never used T enhancements and not a gung-ho about it, but denying there is a link between T level's in men and successes in sports, leadership and other avenues of life is a total rubbish!
𝖕𝖗𝖔𝖒𝖔𝖘𝖒 🔥
Personal success ≠ success on paper
so touching for an excellent video
Here is a link to the second half that he mentions: Sander Greenland: Advancing Statistics Reform, Part II mediaserver.unige.ch/play/151325 given at the University of Geneva Global Studies Institute
thanks