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EKG Science
Australia
เข้าร่วมเมื่อ 17 เม.ย. 2021
We believe you have the power to write your story. ✏️
Whether you’re in high school, university, or just want to learn something new, EKG science wants to be part of your story.
Be a sweet neuron, and subscribe for weekly videos!
Remember, subtract complexity & slow down. 💙
Whether you’re in high school, university, or just want to learn something new, EKG science wants to be part of your story.
Be a sweet neuron, and subscribe for weekly videos!
Remember, subtract complexity & slow down. 💙
Drug Metabolism - Pharmacokinetics | Pharmacology
🧬 Subscribe for more science lectures:
th-cam.com/users/EKGScience
In this lecture EKG is going to cover drug metabolism. We're going to look at the processes involved in drug metabolism, including phase 1 and phase 2 reactions, as well as the key enzymes that catalyse these reactions. We're also going to break down the CYP450 system and explore what induces and inhibits these enzymes.
Feeling a little under the dose of pharmacology? Subscribe to the channel and we'll fill your prescription with more pharma content! Seriously though be an agonist drug and bind to the subscribe button 😉
Lecture Overview:
0:00 Intro
0:58 Definition, Purpose & Location
2:05 Overview: Lipophilic vs Hydrophilic Drug
3:25 Overview: Phase 1 & 2
5:40 Types of Metabolites
7:30 Phase 1 Reactions, CYP450 Enzymes & Genetic Polymorphism
11:45 Phase 2 Reactions
14:12 Factors Affecting Drug Metabolism
15:30 Enzyme Inducers
18:55 Enzyme Inhibitors
✏️ All diagrams were made by EKG.
For educational purposes only; NOT medical or other advice.
Lecture Source:
Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier.
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📚 STUDY NEXT:
🌏 Our mission here at EKG Science is to serve the current and future generations of learners by creating free, world-class science lectures.
Write your story.
Remember, subtract complexity & slow down.
#pharmacokinetics #pharmacology #ekgscience
th-cam.com/users/EKGScience
In this lecture EKG is going to cover drug metabolism. We're going to look at the processes involved in drug metabolism, including phase 1 and phase 2 reactions, as well as the key enzymes that catalyse these reactions. We're also going to break down the CYP450 system and explore what induces and inhibits these enzymes.
Feeling a little under the dose of pharmacology? Subscribe to the channel and we'll fill your prescription with more pharma content! Seriously though be an agonist drug and bind to the subscribe button 😉
Lecture Overview:
0:00 Intro
0:58 Definition, Purpose & Location
2:05 Overview: Lipophilic vs Hydrophilic Drug
3:25 Overview: Phase 1 & 2
5:40 Types of Metabolites
7:30 Phase 1 Reactions, CYP450 Enzymes & Genetic Polymorphism
11:45 Phase 2 Reactions
14:12 Factors Affecting Drug Metabolism
15:30 Enzyme Inducers
18:55 Enzyme Inhibitors
✏️ All diagrams were made by EKG.
For educational purposes only; NOT medical or other advice.
Lecture Source:
Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier.
---
💙 SUPPORT EKG SCIENCE
PayPal - www.paypal.com/paypalme/ekgscience
📸 SOCIAL MEDIA
Instagram - ekgscience
Twitter - ekgscience
📚 STUDY NEXT:
🌏 Our mission here at EKG Science is to serve the current and future generations of learners by creating free, world-class science lectures.
Write your story.
Remember, subtract complexity & slow down.
#pharmacokinetics #pharmacology #ekgscience
มุมมอง: 231
วีดีโอ
Drug Distribution - Pharmacokinetics | Pharmacology
มุมมอง 3782 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture EKG is going to cover drug distribution. We’re going to break down what drug distribution is, the factors influencing this process, body fluid compartments and the apparent volume of distribution. Feeling a little under the dose of pharmacology? Subscribe to the channel and we'll fill your prescription with more ...
Drug Absorption - Pharmacokinetics | Pharmacology
มุมมอง 5263 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture EKG is going to cover drug absorption. We’re going to break down what drug absorption is, the factors influencing this process, the different routes of administration, and the mechanisms of absorption. Feeling a little under the dose of pharmacology? Subscribe to the channel and we'll fill your prescription with ...
Introduction to Pharmacokinetics: ADME Overview | Pharmacology
มุมมอง 2.1K8 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture EKG is going to cover an introduction to pharmacokinetics, looking at an overview of the four main processes, which are absorption, distribution, metabolism, and excretion. We’ll also break down some key pharmacokinetic concepts, such as bioavailability, first-pass metabolism, and half-life, describe their clinic...
G-Protein Coupled Receptors (GPCRs) & Second Messenger Systems | Pharmacology
มุมมอง 8649 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture EKG is going to cover G protein-coupled receptors (GPCRs) and second messengers. We’re going to break down the structure of GPCRs and G proteins and how the binding of an agonist drug leads to the activation of that G protein. Then we’ll explore what second messengers are, looking at the phospholipase C/inositol ...
Drug-Receptor Interactions: Affinity, Efficacy, CRCs & Antagonism
มุมมอง 3.5K9 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture EKG is going to cover drug-receptor interactions. We’ll explore important concepts like drug binding, affinity, efficacy, potency, and concentration response curves. We’ll also break down the role of agonist drugs and dive into the different types of antagonism. Feeling a little under the dose of pharmacology? Su...
Types of Receptors: Ligand-Gated, GPCRs, Kinase-Linked & Nuclear Receptors | Pharmacology
มุมมอง 3.3K10 หลายเดือนก่อน
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover the four main types of receptor proteins: Ligand-gated ion channels, G-protein-coupled receptors, Kinase-linked and related receptors, and nuclear receptors. We’ll describe each receptor’s structure and function and identify key examples of drugs that interact with these receptors. In the p...
Introduction to Pharmacodynamics | Pharmacology
มุมมอง 17Kปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover an introduction to pharmacology and introduce you to one of the fundamental concepts, which is pharmacodynamics. It's the study of how drugs produce their biological effects and how drugs will affect the different systems of the body. In other words, what does the drug do to the body? We’re...
Cardiovascular System Overview: Structure & Function
มุมมอง 457ปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover an overview of the human cardiovascular system. We're going to break down the functions and overall organization of the cardiovascular system, and we’re also going to follow the path of a drop of blood through the heart and circulatory system. In the end, we're going to briefly talk about t...
Synapses (Transmission): Electrical & Chemical | Neurology
มุมมอง 4Kปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover the structure of the synapse and the mechanisms neurons use to send signals across it (synaptic transmission). We’re also going to take a look at the different types of neurotransmitters and receptor proteins. Lecture Overview: 0:00 Intro 0:23 Synapse Definition 2:03 Electrical Synapse (Gap...
Cell Cycle Regulation | Cell Biology
มุมมอง 13Kปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover the regulation of the cell cycle, looking at what initiates the cycle and what stops it from continuing. We're going to break down the cell cycle checkpoints-the factors that determine whether or not the cycle will progress or not-and the cell cycle control system. Next, you're going to lea...
Cell Cycle: Interphase & Mitosis | Cell Biology
มุมมอง 1.6Kปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover the cell cycle, which includes interphase and mitosis. We're going to break down the importance of the cell cycle, how DNA is organized, the subphases of interphase, and the events that take place during mitosis. Lecture Overview: 0:00 Intro 0:28 Cell Cycle Overview 2:20 Cellular Organizati...
Glomerular Filtration (GFR) | Renal Physiology
มุมมอง 548ปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover glomerular filtration, which is the first step in urine formation. We're going to break down the structure of the renal corpuscle, the 3 layers of the filtration barrier, the juxtaglomerular apparatus, the starling forces, and finally the factors that determine the glomerular filtration rat...
Anatomy Of The Kidney & Urinary System | Renal Physiology
มุมมอง 728ปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover the anatomy and overview functions of the kidneys and the urinary system. We're also going to break down the kidney blood supply, the structure of nephrons, and the important physiological processes. Make sure to smash the like button and subscribe to the channel so that we can hit 1 millio...
Resting Membrane, Graded & Action Potentials | Neurology
มุมมอง 767ปีที่แล้ว
🧬 Subscribe for more science lectures: th-cam.com/users/EKGScience In this lecture, EKG is going to cover resting membrane potential, graded potentials, and action potentials of neurons. We're going to break down what membrane potential is and what generates and maintains resting membrane potential. You'll discover the distinction between excitatory and inhibitory postsynaptic potentials, as we...
Photosynthesis: Light Dependent Reactions & Calvin Cycle | Cell Biology
มุมมอง 891ปีที่แล้ว
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Cellular Respiration: Aerobic & Anaerobic | Cell Biology
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Glial Cells: Astrocytes, Oligodendrocytes, Schwann Cells, Microglia, Ependymal Cells
มุมมอง 962ปีที่แล้ว
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Membrane Transport: Passive & Active | Endocytosis & Exocytosis | Cell Biology
มุมมอง 595ปีที่แล้ว
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Pharmacokinetics: Absorption, Distribution, Metabolism & Excretion
มุมมอง 36Kปีที่แล้ว
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Cell Membrane Structure: Lipid Bilayer & Proteins | Cell Biology
มุมมอง 519ปีที่แล้ว
Cell Membrane Structure: Lipid Bilayer & Proteins | Cell Biology
A Tour Of The Cell: Structure & Function | Cell Biology
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Transcription & Translation: From DNA To Protein | Cell Biology
มุมมอง 468ปีที่แล้ว
Transcription & Translation: From DNA To Protein | Cell Biology
Translation: Protein Synthesis (RNA To Protein) | Cell Biology
มุมมอง 5582 ปีที่แล้ว
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DNA Transcription (DNA To RNA) | Cell Biology
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DNA Transcription (DNA To RNA) | Cell Biology
DNA Repair & Recombination | Cell Biology
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DNA Repair & Recombination | Cell Biology
DNA Structure, Function & Organization | Cell Biology
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DNA Structure, Function & Organization | Cell Biology
Protein Structure, Function & Regulation | Cell Biology
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Tnk u mam
You have covered a huge amount of information in just 14 minutes, this is incredible. Thank you so much for this wonderful work.
Your classes are fantastic. You should carry on with more lectures
Appreciate you!!
Thanks alot. I've been watching your series on Pharmacokinetics. It's very well explained and clear. Keep up the great work.
very helpful
Glad it helped!
5:35 Isn't branching supposed to increase the number of non-reducing ends? Because glycogen only has one reducing end
Pliz keep doing more lectures. You an excellent tutor.
❤❤❤ thank you easy to understand
Happy to help 💙
very helpful lecture, thank you!
Glad it was helpful!
Really good video, thanks a lot. Greetings from Spain
You are a gold and helped me so much!!!! Please keep doing these!!!
Appreciate you! Happy to hear it’s helped you 🙌🏽
I really seek this channel for my every biochemistry sections
Great to hear it’s helped you!
Been using your videos on cell biology to study for my course and its saved me, thank you so much!!!
That’s awesome!! Happy to help 🙌🏽
How induction and inhibition affect drug dosing? (Prodrug or convectional drug)❤ Thank you so much
It can cause significant drug interactions; therefore, therapeutic drug monitoring may be necessary to ensure optimal dosing and avoid any adverse effects or treatment failure.
@@EKGScience thank you , I hope elimination will be soon, before my exam 🥰🌹❤
I bave questin- Which phase of metabolism is just before the elimination?
Once a drug enters the body, the process of elimination begins (hepatic, biliary, and urinary). Elimination involves both metabolism and excretion. When considering the sequence of events leading up to the removal of the drug from the body, phase 2 metabolism usually occurs before then. It involves conjugation reactions that make the drug or phase 1 metabolites more suitable for excretion. However, if the metabolites from phase 1 are sufficiently polar, they can be excreted by the kidneys. Many phase 1 metabolites are still too lipophilic so phase 2 occurs. I hope that helps!
I hope you get lots more views and subscribers! Your content is top notch 💎
Appreciate you! Glad you found the channel 🥹
Thank you so much for this
Perfect explanation, thanks for the knowledge share.
Glad it was helpful!
Thank you so much. Excellent content.
❤❤
Hi Can I ask for a copy of your presentation?
You're so good at explaining and thank you for starting from the complete basics before covering it in a perfect amount of detail for uni lvl 4 ❤
I’m glad you found it helpful 💙
Fantastic explanation and overview of PK :) now I just need metabolism and excretion please :)
Tha k this was really helpful !
At 4.47 she says acyl glycerol lipase but on the screen it shows agtl. On other videos people call it adipose tissue lipase. Which is correct ?
I dont get why your videos have so little views, youre so good at explaining and deserve more views and subscribers 😍
Appreciate you 🥹 Glad you found the channel!!
Okay I just subscribed. I hate that I found your channel late.
You are an amazing teacher, speaker and woman. Much appreciated!!!
Appreciate you! Glad you found the channel 🙌🏽
A very comprehensive lecture from such a young lecturer, thanks for impacting us with your knowledge
Appreciate you 💙
Pretty and smart ❤
This is amazing
It would seem that raising CO2, thus lowering pH would also aid in the inhibitory affects of IF1.
Excellent Video! Just one question: F0 of ATP Synthase is made up of 12 subunits, while F1 has 6 parts but only 3 moving. It takes 4 protons to make 1 ATP, based on the mechanics of the enzyme. If Complex 1 makes 4 protons from 1 NADH, how do we get 2.5, when conventional wisdom would assume just 1 per molecule of NADH?
At 1.09 she says the acetyl coa can enter the ca cycle or turn into ketones? But what determines what happens?
You are saving my life... so happy to find your channel.
Ingles is not my first language it as been so difficul for me to understand I have been strugle with this concepts for while, I tried a lot of videos none of them explain as clear as you did... you are the best you make it easy....! So sad I haven't find you before my assesement but still it will be helpful for my final exam...... thank you so much : - ) please don't stop.
I’m glad to hear the lectures have helped and you found the channel! Appreciate you ☺️
Your video is amazing ❤. We need drug metabolism plz create a video.
Appreciate you 💙 it’s currently in the works!
I hardly wait your favorite process-metabolism❤
@@nerma-yy3ke Currently editing it today!!
Thanks for ur explanation..its very helpful to me❤
Glad it was helpful! 💙
Can I have this lecture as a PDF
the accent is giving, miss maaaammmmmmm
Very helpful... thank you!!! :)
Glad it was helpful! 😊
Thank you so much, that was amazing❤
Appreciate you 💙
❤❤
Awesome!!!🎉
You are really amazing 💕🙏🏻
Appreciate you 💙
amazing thankyou very much please dose response effects
It's been awhile. I hope everything's been okay with you.
I’ve been busy with university! Finally can post more lectures 😊
Are you studying pharmacy? I am and your channel is incredible for my study!@@EKGScience
wooow that's was an amazing lecture. please continue for us
I appreciate it!!
Shes so fine bro