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ShortChemistry
เข้าร่วมเมื่อ 18 มี.ค. 2019
Hey folks... Dr. Alan Doucette here. I'm a professor of Chemistry at Dalhousie University, in Halifax, Canada. I specialized in chemical analysis, and over the years as a research scientist, I've created several new tools to better characterize biological systems - especially when it comes to protein analysis. I'm also passionate about teaching. So I put these videos together to help my students visualize some of the concepts presented in various analytical courses. I welcome your feedback, and will continue to post new videos that I hope will one day help you in your studies.
ChatGPT and the rise of AI
No, I don't think the machines are going to rise up and take over the planet. But as an educator, I'm excited (and maybe a little scared) for the future potential of ChatGPT. What opportunities lie ahead? What challenges will it bring?
มุมมอง: 547
วีดีโอ
Midterm 2 answers and review
มุมมอง 1.2K2 ปีที่แล้ว
This midterm covered the various mass analyzers, modes of ionization, with applications in proteomics and small molecule fragmentation (EI)
Solutions to Midterm 1
มุมมอง 1.3K2 ปีที่แล้ว
These are the questions and answers to our first midterm. Skip ahead to the individual questions through the following timestamps: 0:00 INTRO 0:53 Determining an unknown formula based on accurate mass 10:00 Predicting the isotope pattern of a compound 18:33 Calculating mass accuracy based on a multiply charged ion 27:00 Qualitative vs quantitative analysis: GC-MS & LC-MS/MS 37:27 (Bonus Questio...
What research looks like
มุมมอง 1.3K2 ปีที่แล้ว
Here's an example of an ongoing research project out of my chemistry lab at Dalhousie University. It's still a 'work in progress', but hopefully you get a sense of the process we use to design and test a new instrument.
Environmental Racism and Mass Spectrometry
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Mass spectrometry is a scientific instrument - a tool, that can be used to characterize chemical compounds. In this video, Claudia Flynn showcases the use of mass spec to profile environmental contaminants, and raise awareness of how indigenous communities are disproportionately affected by these contaminants.
Fragmentation in mass spectrometry
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Whether it's by electron ionization, or tandem mass spectrometry, the formation of fragment ions is not a random process.
Top down vs bottom up proteomics
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Two different strategies we can use to identify proteins with mass spectrometry.
Proteome analysis workflows
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Mass spectrometry plays an essential role in proteomics analysis. But so do many other tools, including separation.
Proteomics vs Genomics
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Sequencing DNA is easy. Proteomics analysis has extra challenges, but it can help answer many questions that genomics cannot.
MALDI mass spectrometry
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Matrix-assisted laser desorption/ionization mass spectrometry comes in two different flavours.
Study Montage
มุมมอง 7K3 ปีที่แล้ว
The key to success is proper preparation. This video is part of a longer video on this channel dealing with how to solve difficult problems. Here's a link to that video. th-cam.com/video/vj2tWWJfrS0/w-d-xo.html
Electron ionization and mass spectrometry
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We talk about chemical ionization and APCI (atmospheric pressure chemical ionization) as well.
Non Ideal solutions, activity and Ionic Strength
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Non Ideal solutions, activity and Ionic Strength
Everything you know about strong acids is wrong
มุมมอง 8393 ปีที่แล้ว
Everything you know about strong acids is wrong
Super
Wonderful job sir.everyone must watch this.
Thank you very much. Extremely helpful
amazing
One of the best lecturers
The very best concise explanation! Thank you.
all your videos are clear, thank you !
Wow ! Thanks. Like to know more about any proactical everyday use of Quadrople Ion Trap M.S. Any applications for early detection of brain health in humans for example ?
bruh im just a random phd first year doing research and found your channel super helpful getting preped for my career...
Hi, for determination of K percentage in a fertilizer, I make calibration curve mixing standards and unknown. As 10 ml of unknown to all balloons and different amounts of standard, 1 balloon only has unknown without any standard. Why is that? Shouldn't the b from y=ax+b and signal of the balloon without standard be the same? If they are not what should I do? I'm confused, please help
perfect perfect perfect
"welcome to your first mountain stage 😅" Great video btw
Thanks a million for all your great videos on MS Spect., you did a great job in presenting a high tech and complicated topic in a simple and understsndable way. I really enjoed watching them.
You deserve so much recognition! Amazing ❤
Amazing ❤!
Well explained and a wonderful instrument. Thank you! 👏
Thank you so, so much
Hello, could someone explain how you find an hexane from counting 3 CH2 and 1 CH3 at 11:37 please ? Where do you see the other 2 CH2 ?
that's the best explanation i found! thank you.
really good explanation, thank you:)
Thank you
Subscribed, you explain really well. Congrats!
You are a lifesaver and an excellent teacher, many thanks
Thanks!
Some use elemental analyzer before doing all this, why is that?
Fantastic video , love the jokes in the middle😂
I am a proteomics professor in France. Your course is just great. thank you
#Left hand gang
Great explanation
i am sorry i have to bring this up, i am a master student and i was studying for my exam on this subject and randomly came across your video which was of great help. i noticed your name is alan doucette, and you look just like a famous fintess youtuber i have been following for years. are you greg doucettes brother?!! my god you look just like him
He is!
You are a magician
The way you explain these topics in your videos is just phenomenal! Keep up the good work!
Watching this while working on A. Chem on my way to get a forensics degree! Glad you brought up how important this aspect is for the field!
saved my life
I've struggled to understand mass accuracy in MS for years now and finally I have a grasp on it now!! THANK YOU FOR CREATING THIS CONTENT!!!! PPM and PPB were so frustrating to me, and now in under 10 minutes it all clicked.
Thank you so much for this, this was super helpful :)
thank you so much, your videos have been helping me finish my undergrad!!!
This really helped me to understand the differences between spectra acquisition modes! Thank you
8:50 the one thing you missed out on mentioning is the inverse square law. If you plot the potential energies of the ions between two poles, you get either a knife-edge (i.e. 1/x^2) where small ions roll off, big ones don't have time. Or you get a parabola-shaped ditch (x^2) where the big ions have enough momentum to get all the way up the walls. Don't know if it'll help anyone else, but I always like watching balls roll down planes.
Need subtitles T^T ~~
best explanation ever..
@4:17, "The low mass compounds that have the mass defect." should be "mass sufficiency"?
10:00 LOL, so funny
can anyone tell me why there's error between website calculation and hand calculation? When both methods calculated, there is no charge. So this "error" is just used for mentioning that small difference can be detected by MS?
Wow, it's amazing! "carbon 12 by definition has a mass of exactly 12, and therefore, if you look at carbon 13, it is not the mass of carbon 12 plus one neutron. It's a little bit less than that." You explain this extremely clear!!!
Thank you this was very useful
It's awesome!!!brilliant!! Thank you
super good!
Any differences between the d and l form of glutamine are not due to differerences between the d and l form of gritainnes in the MS. These enantiomers fragment in exactly the same way.
McLafferty rearrange is the retroene reaction. Look at the mechanism and sort out for yourself why this should be the low-energy sigmatropic process.