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My dog was diagnosed with autoimmune brain inflammation six months ago. In addition, she had minimal brain herniation. In November, one night she was pacing and restless. I took her to the vet thinking she had a relapse. They gave her serums. My maltese developed very severe head tilt and excessive drooling after taking Mannitol and corticosteroids serum. When I take her to the vet she was able to walk and conscious. Within a few hours after taking those serums she had severe neurological symptoms and not able to walk either. We called the vet and she gave her Mannitol serum again. She died in 3 days in pain. She was only 3.5 years old. Did those serums kill my pup?

Hi doc, what do you think about the emerging new gabapentinoid, mirogabalin?

Thank you for your unbiased and straightforward review. I was looking into this for my cat who is experiencing pain from a leg injury. I think I'm going to hold off because I too could not find any scientific reviews. Thanks again

All I have to say is thank you for this video. I have a lovely boy going through the diagnosis stage and this has really helped understand what is going on! Thank you!

Please tell about same for cats. We have this unique kitty in Ukraine Kyiv.

Very good case .

Any opinion on if UC11- (type two collagen) will help?

Such an inspiring neuro!

Thanks for sharing.❤🎉

Great, thanks! I'd be most grateful for a neuro exam check sheet if you wouldn't mind sharing it please? (Cavalier mad Ophtho here).

Thank you this information is really helpful. Love you channel. Keep up the great work!

Thank you!

Thank you for the helpful information 💜🐈🐈‍⬛🐕

Thank you. I love your videos

Thanks for the video

An observation about the weight-gain aspect - completely anecdotal - my kitty is a big boy and he was initially given this drug after tooth removal and I noticed a huge improvement in how he coped with back pain. My vet was concerned about weight gain long-term, but when he is on the drug he is more active, and when he is in pain he comfort-eats. There was actually a notable weight loss on the drug. These days I give it to him only when he is having a really bad day to offer some relief.

So helpful and interesting. My Cavalier, Misha, was on phenobarbital for 3 years but my vet didn’t do any monitoring at all! Misha was on the heavy side to begin with but within two years of being on this med he’d put on 3 kilos! So I asked my vet to put him on another epilepsy med (the expensive one) but it seemed to make him agitated and he was still obsessed with food. So now I’ve taken him off all epilepsy meds. He only has a fit about once a month and the Gabapentin he takes for SM really helps with keeping them short - usually around the one minute mark. I time them and keep a seizure diary and always have rectal diazepam at the ready in case the seizure goes on for too long. But as Misha is also on steroids and Gabapentin, both of which also cause weight gain, I felt that the increase of appetite caused by the epilepsy med was more of a threat to Misha’s life than allowing him to have the actual seizures.

Thanks for sharing 😊

Very interesting and helpful, thank you.

Fab! Thank you very much

Thank you for this! My boy Bilbo (a Maine coon) was referred to the incredible team at Dick Whites and tested positive for the LGI1 antibodies. He was showing signs of hyper salivation, involuntary urination, unaware of his surroundings and vocalisations. He responded incredibly well to a course of prednisolone, phenobarbital and leviteracitum and went 3 months without seizures. Unfortunately the seizures returned when we tried to lower the dose so he’s back up to his normal dose of Leviteracitum and phenobarbital and we are trying a course of prednisolone again whilst we wait for his bloods. He has the odd seizure every now and again but they are nowhere near are severe or frequent. (He was having 5 a day before his referral). It’s good to know we aren’t alone and that Muddis is doing okay ❤

Thank you for sharing this information. Harry is currently being treated for suspected limbic encephalitis. He had h8s first seizure on Friday and managed to get into Liverpool small animal teaching hospital on Saturday. His MRI on Sunday shows possible limbic. We are waiting results of the blood test. We are struggling to get his seizures under control at the moment, but after reading about Muddis I feel a little more optimistic. Thanks again.

Hi Professor! Thanks for such an informative video. I was searching everywhere for some information regarding Pregabalin dosage for cats with FHS. We transitioned from Gabapentin at 100mg twice daily several months ago as my cat started refusing to take the meds in her food. We commenced Pregabalin at 25mg twice daily and in fact, her symptoms seemed improved. That was until the last week or so when she started tail biting/attacking again. I called my vet today who said to increase her dose to a total of 75mg daily (either 25mg x 3 or 3 capsules split into two doses). I’m concerned that this is too high a dose? She weighs around 6.3kg (gained weight since starting Pregabalin 🫣) I did give her a second 25mg dose today around 8hrs after the first with a plan to give her a third one before bed, however the second one really made her quite sedated/sleepy? Is this normal? She was never this quiet with the 2 x 25mg daily given roughly 12hrs apart. Thanks so much for your invaluable advice 😻

Hi we have a 9 year old Chihuahua that was diagnosed by MRI having Chiari malformation. The doctor has advised against surgery and our dog is now on medication since 5 weeks. The medication is 1x 5 mg dermipred, 1x 5mg Losec-mups, and 2x 25mg Lyrica a day. In the beginning of the treatment we saw a big improvement in his condition when dermipred 5 mg was given. His condition was the he lost like 70% of his strength from one minute to the other and could barely stand on his feet, Falling regularly on his face while walking. Since dermipred i would say his strenght is now at 50% but he is not getting stronger. We also tried 3x gabapentine instead of the 2x 25mg Lyrica when we started the treatment but it seems that while his condition improves, it does not seem to be enough to get him trough a full day without pain. I am reaching out to everyone who has expertise on this terrible disease to get as much information on how to improve his life. All information is very welcome thank you.

My dog has been diagnosed with CM/SM, and every time after she eats, she runs to my bed and energetically rubs her head, then burrows under the blankets or pillows. In the end, she sticks her head back out.Before the diagnosis, I always thought she was just having zoomies because she enjoyed her food. Now I constantly wonder if she's in pain after eating since she only does this after meals. How can I tell if eating is causing her pain? Is that possible, and if so, why?

Thanks for the video and the book recommendation! Great read!

Thank you, Claire -- very nice summary. I will add that over the last 14 years we have not had a repeat surgery. I do exactly what you illustrated here (FMD, duroplasty, and SIS). I suture the SIS over the duroplasty defect and then place an autologous fat graft over the site. Like you, we don't have all the follow-up we would like, but in a coupe of cases, the repeat MRI at 3 years has shown the fat graft in place. Significant reduction in the syrinx, as you have said, is uncommon, but improvement is not uncommon -- at least on all of our follow-ups, we have always seen improvement -- usually with medications, sometimes not. I will say that we have seen a reduction in the syrinx in patients we perform this at less than 2 years of age. Many thanks! Andy

Thank you so much for this information. My 6 year old Cavalier 11 kilos developed SM about a year ago, we don’t have MRI available in Tasmania and it would be very expensive and not worth doing unless you were having the surgery done. Willow has been on Gaberpentin 100 mg and ended up having 5 or so capsules a day for about 10 months. Another vet recently changed her to Pregabalin 25 mg capsules 2 twelve hours apart, as she had some breakthroughs we give 2 at night and 3 spread out through the day but Im wondering if they are better given two together maybe 3 time in 24 hours. She dosen’t yelp in pain but does head rubbing body twisting and some scratching. Still likes her walks etc and quite bright but yes has put on a lot of weight, doesn’t have heart trouble at the moment. Unfortunately my vet has not had a lot odd cases of SM so prefers if I do my own research. Thank you Liz.

I want to thank you so much for this beautiful presentation... I am so grateful that one of you genius' has found a way to spell this out in laymen's terms..... I am currently fighting off any signs of suffering in my 13 year old Cav with gabapentine prednisone, prilosec, and CBD. As well as treating her heart murmur with cardiac meds.... I refuse to allow her or any of my sweet pups suffer but the comfort measures can only take us so far before we need to make a hard decision...

Such a helpful and interesting video! Do you think that dogs with idiopathic epilepsy who used to have seizures no more frequently than once a month and who have now put on excessive weight due to Phenobarbital should be switched to Imepitoin? A lot of vets who put epileptic dogs on Phenobarbital don't ever bother monitoring their blood or checking their livers, so maybe it would be a safer option too in that case?

Very useful video！ The NSAID drug you mentioned in the video, is called "grappa print"? can you tell me the right name plz？

Hello doctor, thank you very much for this video. My dog, a 10 year 7 month old golden retriever, was treated with radiation therapy treatment (for brain meningioma) 4 months ago, and she has been on a mild dose of pregabalin 100 mg 2x 1 tablet daily (3 mg /kg twice daily) for the last 4 months. Recently, we observed a strange head twitching for half an hour; during this time, she was completely active and responsive. Could you please advise if it could be a side effect of pregabalin that showed as a myoclonus-type seizure? If Pregabalin is tapered down and eventually stopped, will it help her? The other anti-epileptic drug my dog takes is Levetiracetam 500 mg 3x 2 tablets daily. Please suggest. Thank you very much.

Very good. Thanks ❤

Thank you for an excellent presentation. I have a question. Are UC-II collagen supplements contradicted when a dog is on long term Pregabalin treatment? The literature does not seem to address that question. Thank you

Thank you, it was important for me to hear that cats liver does not filter as readily as dog livers. I will be mindful of that.

My little Maltese just went for an MRI for a slipped disc & they discovered he has this 😢 hopefully picking him up later today.

What an interesting case ! Thank you !

Very clear explanation thank you, helps me better how to manage as a person with a dog that has a spinal injury

Brilliant thank you

This was a fascinating video, thank you!

Hello :), I just wanted to say thank you so much for these videos! I am currently studying for my Board exams in Veterinary Behaviour Medicine (American & European Colleges) and have loved watching and listening to your videos for some of the psychopharmacology and the neurology that I need to know !! Thanks again !!

Fantastic delivery Prof. Had a couple of cases managed with Polypharmacy and Swimming hydrotherapy with excellent recovery process. I'm glad you clearly stated cage/crate rest should be well defined to Pet owners. With this i'm more confident to help Pets with IVDD and i hope to learn more from great tutors Like you in future. Thanks Once again Prof.

Fantastic delivery Prof. Had a couple of cases managed with Polypharmacy and Swimming hydrotherapy with excellent recovery process. I'm glad you clearly stated cage/crate rest should be well defined to Pet owners. With this i'm more confident to help Pets with IVDD and i hope to learn more from great tutors Like you in future. Thanks Once again Prof.

Thank you for the great explanation

Thank you for the informative video! My doxie was recently diagnosed with lvl 2 IVDD. Took MRIs and decided to go the conservative route since her pain was manageable with medication and the hernia was relatively small. I’m already seeing a huge improvement in her walking after 5 days. Will be starting physiotherapy and hydrotherapy tomorrow 😊 Biggest difficulty this far has been keeping her resting, as she’s full of energy now that we’ve found effective pain management!

I used to be scared of neurology because I found my teacher in uni to be very confusing, but watching your videos and also your presentations at the ISFM Congress have made me feel more confident! Thank you very much!

Very good. Thanks 🎉

Thanks for sharing this case .

Good video!