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CardioNerds
เข้าร่วมเมื่อ 6 ธ.ค. 2019
408. Journal Club: The SUMMIT Trial with Dr. Milton Packer
Join CardioNerds Heart Failure Section Chair Dr. Jenna Skowronski, episode lead Dr. Merna Hussein, and expert faculty Dr. Milton Packer as they discuss the SUMMIT trial (www.nejm.org/doi/full/10.1056/NEJMoa2410027) .
The SUMMIT trial randomized 731 patients with HFpEF with LVEF ≥ 50% and obesity with BMI ≥ 30 kg/m2 to receive tirzepatide or placebo for at least 52 weeks. The two co-primary endpoints were a composite of time to cardiovascular death or a worsening heart failure event and quality of life measured by the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS). Treatment with tirzepatide led to a lower risk of the composite of cardiovascular death or worsening heart failure as well as improved quality of life.
This episode was planned in collaboration with the American College of Cardiology Section of the Prevention of Cardiovascular Disease with mentorship from Section Chair Dr. Eugenia Gianos. (www.acc.org/Membership/Sections-and-Councils/Prevention-of-Cardiovascular-Disease-Section#sort=%40commonsortdate%20descending)
Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. (www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061404)
US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. (www.uscjournal.com/articles/case-primary-cardiac-b-cell-lymphoma-diagnosed-cardiac-mri)
CardioNerds Journal Club Page (www.cardionerds.com/cardsjc/)
CardioNerds Episode Page (www.cardionerds.com/episodes/)
CardioNerds Academy (www.cardionerds.com/academy/)
Cardionerds Healy Honor Roll (www.cardionerds.com/honor-roll-ambassadors/)
CardioNerds Journal Club
(www.cardionerds.com/cardsjc/) Subscribe to The Heartbeat Newsletter! (eepurl.com/hazGYL)
Check out CardioNerds SWAG! (teespring.com/cardionerds?pid=658&cid=102908)
Become a CardioNerds Patron! (www.patreon.com/cardionerds)
References - The SUMMIT Trial
Packer, M., Zile, M. R., Kramer, C. M., Baum, S. J., Litwin, S. E., Menon, V., Ge, J., Weerakkody, G. J., Ou, Y., Bunck, M. C., Hurt, K. C., Murakami, M., Borlaug, B. A., & SUMMIT Trial Study Group. (2024). Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. The New England Journal of Medicine. doi.org/10.1056/NEJMoa2410027
The SUMMIT trial randomized 731 patients with HFpEF with LVEF ≥ 50% and obesity with BMI ≥ 30 kg/m2 to receive tirzepatide or placebo for at least 52 weeks. The two co-primary endpoints were a composite of time to cardiovascular death or a worsening heart failure event and quality of life measured by the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS). Treatment with tirzepatide led to a lower risk of the composite of cardiovascular death or worsening heart failure as well as improved quality of life.
This episode was planned in collaboration with the American College of Cardiology Section of the Prevention of Cardiovascular Disease with mentorship from Section Chair Dr. Eugenia Gianos. (www.acc.org/Membership/Sections-and-Councils/Prevention-of-Cardiovascular-Disease-Section#sort=%40commonsortdate%20descending)
Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. (www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061404)
US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. (www.uscjournal.com/articles/case-primary-cardiac-b-cell-lymphoma-diagnosed-cardiac-mri)
CardioNerds Journal Club Page (www.cardionerds.com/cardsjc/)
CardioNerds Episode Page (www.cardionerds.com/episodes/)
CardioNerds Academy (www.cardionerds.com/academy/)
Cardionerds Healy Honor Roll (www.cardionerds.com/honor-roll-ambassadors/)
CardioNerds Journal Club
(www.cardionerds.com/cardsjc/) Subscribe to The Heartbeat Newsletter! (eepurl.com/hazGYL)
Check out CardioNerds SWAG! (teespring.com/cardionerds?pid=658&cid=102908)
Become a CardioNerds Patron! (www.patreon.com/cardionerds)
References - The SUMMIT Trial
Packer, M., Zile, M. R., Kramer, C. M., Baum, S. J., Litwin, S. E., Menon, V., Ge, J., Weerakkody, G. J., Ou, Y., Bunck, M. C., Hurt, K. C., Murakami, M., Borlaug, B. A., & SUMMIT Trial Study Group. (2024). Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. The New England Journal of Medicine. doi.org/10.1056/NEJMoa2410027
มุมมอง: 48
วีดีโอ
407. Journal Club: The Nex-Z Trial - A CRISPR-Cas9 Based Treatment for ATTR Cardiac Amyloidosis w...
มุมมอง 3614 ชั่วโมงที่ผ่านมา
Join CardioNerds Heart Failure Section Chair Dr. Jenna Skowronski, episode lead Dr. Apoorva Gangavelli, and expert faculty Dr. Ronald Witteles as they discuss the Nex-Z trial (www.nejm.org/doi/full/10.1056/NEJMoa2412309) . This was a phase 1, open-label trial investigating nex-z, a CRISPR-Cas9-based treatment, in 36 patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The prim...
406. Journal Club: The BPROAD Trial with Dr. Keith Ferdinand
มุมมอง 6419 ชั่วโมงที่ผ่านมา
Join CardioNerds co-founder Dr. Daniel Ambinder, episode lead Dr. Nidhi Patel, and expert faculty Dr. Keith Ferdinand as they discuss the BP ROAD trial (www.nejm.org/doi/full/10.1056/NEJMoa2412006) . The BP ROAD trial randomized 12,821 patients 50 years of age or older with type 2 diabetes, elevated systolic blood pressure, and an increased risk of cardiovascular disease to receive intensive tr...
405. Case Report: Like Mother, Like Son? Peripartum Cardiomyopathy and Infantile Hypertrophic Car...
มุมมอง 72หลายเดือนก่อน
CardioNerds (Dr. Dan Ambinder and guest host, Dr. Pooja Prasad) join Dr. Donny Mattia from Phoenix Children’s pediatric cardiology fellowship, Dr. Sri Nayak from the Mayo Clinic - Arizona adult cardiology fellowship, and Dr. Harrison VanDolah from the University of Arizona College of Medicine - Phoenix Med/Peds program for a sunrise hike of Piestewa Peak, followed by some coffee at Berdena’s in...
404. Case Report: A Stressful Case of Cardiogenic Shock - Tufts Medical Center
มุมมอง 2042 หลายเดือนก่อน
CardioNerds (Dr. Dan Ambinder ( Dr_DanMD) and Dr. Yoav Karpenshif ( YoavKarpenshif) - Chair of the CardioNerds Critical Care Cardiology Council) join Dr. Munim Khan, Dr. Shravani Gangidi, and Dr. Rachel Goodman ( goodmra1) from Tufts Medical Center’s general cardiology fellowship program for hot pot in China Town in Boston. They discuss a case involving a patien...
403. Cardio-Rheumatology: Treating Inflammation and Real-World Implementation of Therapies with D...
มุมมอง 682 หลายเดือนก่อน
In this episode, CardioNerds Dr. Gurleen Kaur ( Gurleen_Kaur96) and Dr. Akiva Rosenzveig (x.com/AkivaRosenzveig) are joined by Cardio-Rheumatology experts, Dr. Brittany Weber ( Bweber04) and Dr. Michael Garshick ( garshick) to discuss treating inflammation, delving into the pathophysiology behind the inflammatory hypothesis of atherosclerotic cardiovascular dise...
402. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #39 w...
มุมมอง 842 หลายเดือนก่อน
The following question refers to Sections 7.3.3 and 7.3.6 of the 2022 ACC/AHA/HFSA Guideline for the Management of Heart Failure. The question is asked by Palisades Medical Center medicine resident & CardioNerds Academy Fellow Dr. Maryam Barkhordarian ( MaryamBMD) , answered first by UTSW AHFT Cardiologist & CardioNerds FIT Ambassador Dr. Natalie Tapaskar ( NatalieTapaskar...
401. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #38 w...
มุมมอง 702 หลายเดือนก่อน
The following question refers to Sections 7.4 and 7.5 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. The question is asked by the Director of the CardioNerds Internship Dr. Akiva Rosenzveig ( AkivaRosenzveig) , answered first by Vanderbilt AHFT cardiology fellow Dr. Jenna Skowronski ( JennaSkowronski) , and then by expert faculty Dr. Randall Starli...
400. Cardio-Rheumatology: Targeting Inflammation for Cardiovascular Risk Reduction with Dr. Paul ...
มุมมอง 742 หลายเดือนก่อน
In this episode, Dr. Paul Ridker, a pioneer in the field of cardiovascular inflammation, joins the CardioNerds (x.com/cardionerds) (Dr. Gurleen Kaur (x.com/RichardAFerraro) , Dr. Richard Ferraro (x.com/RichardFerraroMD) , and Dr. Nidhi Patel (x.com/NidhihpatelMD) ) to discuss the evolving landscape of inflammation as a key factor in cardiovascular risk reduction. The discussion dives into the i...
399. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #37 w...
มุมมอง 892 หลายเดือนก่อน
The following question refers to Section 7.4 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. The question is asked by the Director of the CardioNerds Internship Dr. Akiva Rosenzveig ( AkivaRosenzveig) , answered first by Vanderbilt AHFT cardiology fellow Dr. Jenna Skowronski ( JennaSkowronski) , and then by expert faculty Dr. Clyde Yancy (twitter.co...
48. Critical Bicuspid Aortic Valve Stenosis Complicating Pregnancy - Vanderbilt University
มุมมอง 1472 หลายเดือนก่อน
www.cardionerds.com/48-critical-bicuspid-aortic-valve-stenosis-complicating-pregnancy-vanderbilt-university/
51. Embolic Acute Coronary Syndrome from PFO & Pulmonary Hypertension - Lankenau Medical Center
มุมมอง 1032 หลายเดือนก่อน
www.cardionerds.com/51-embolic-acute-coronary-syndrome-from-pfo-pulmonary-hypertension-lankenau-medical-center CardioNerds (Amit Goyal & Dan Ambinder) join Lankenau Medical Center cardiology fellows (Gwen McNeill and Shaung Ooi) for some Philly cheesesteaks! They discuss a fascinating case of Embolic Acute Coronary Syndrome from PFO and Pulmonary Hypertension. Dr. John Clark provides the E-CPR ...
50. Case Report: Hereditary Restrictive Cardiomyopathy - Duke University
มุมมอง 3022 หลายเดือนก่อน
www.cardionerds.com/50-case-report-hereditary-restrictive-cardiomyopathy duke-university/ CardioNerds (Amit Goyal & Dan Ambinder) discuss a case of hereditary restrictive cardiomyopathy with Duke University cardiology fellows Navid Nafissi and Sipa Yankey, and Marat Fudim, an advanced heart failure attending at Duke University. E-CPR is provided by Dr. Richa Agarwal, fellowship program director...
Symptomatic Aortic Stenosis In Pregnancy
มุมมอง 1382 หลายเดือนก่อน
www.cardionerds.com/48-critical-bicuspid-aortic-valve-stenosis-complicating-pregnancy vanderbilt-university/(opens in a new tab) CardioNerds (Amit & Dan) join Vanderbilt University cardiology fellows (Tara Holder, Majd El-Harasis, and Amar Parikh) for a Sunday morning brunch, Nashville style! They discuss an enthralling case of bicuspid aortic valve with critical aortic stenosis complicating pr...
Narratives in Cardiology: Career Flexibility in Cardiology with Dr. Minnow Walsh
มุมมอง 532 หลายเดือนก่อน
In this episode, Dr. Gurleen Kaur (Cardiology FIT at Brigham and Women’s Hospital and APD of the CardioNerds Academy) and Dr. Diane Masket (Medicine Resident at the University of Chicago Northshore and CardioNerds Academy Intern) discuss with Dr. Minnow Walsh (Medical Director of the Heart Failure and Cardiovascular programs at Ascension St. Vincent Heart Center in Indianapolis) about her perso...
397. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #36 w...
มุมมอง 402 หลายเดือนก่อน
397. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #36 w...
396. Case Report: Unmasking Constrictive Pericarditis Using Multimodality Imaging - University of...
มุมมอง 262 หลายเดือนก่อน
396. Case Report: Unmasking Constrictive Pericarditis Using Multimodality Imaging - University of...
395. Beyond the Boards: Channelopathies with Dr. Michael Ackerman
มุมมอง 302 หลายเดือนก่อน
395. Beyond the Boards: Channelopathies with Dr. Michael Ackerman
394. 3rd Annual Sanjay V. Desai Lecture: Artificial Intelligence in Medical Education with Dr. Ka...
มุมมอง 222 หลายเดือนก่อน
394. 3rd Annual Sanjay V. Desai Lecture: Artificial Intelligence in Medical Education with Dr. Ka...
393. SGLT Inhibitors: Clinical Implementation of SGLT Inhibitors with Dr. Alison Bailey
มุมมอง 272 หลายเดือนก่อน
393. SGLT Inhibitors: Clinical Implementation of SGLT Inhibitors with Dr. Alison Bailey
392. Case Report: Heart Failure Out of the Blue, A Case of Cobalt Cardiomyopathy - Georgetown Uni...
มุมมอง 102 หลายเดือนก่อน
392. Case Report: Heart Failure Out of the Blue, A Case of Cobalt Cardiomyopathy - Georgetown Uni...
391. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #35 w...
มุมมอง 152 หลายเดือนก่อน
391. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #35 w...
390. Cardio-Rheumatology: Deciphering Cardiovascular Risk in Patients with Rheumatologic Conditio...
มุมมอง 212 หลายเดือนก่อน
390. Cardio-Rheumatology: Deciphering Cardiovascular Risk in Patients with Rheumatologic Conditio...
389. Case Report: When “Normal” Cholesterol is Not Normal: Exposing an Unusual Presentation of Fa...
มุมมอง 312 หลายเดือนก่อน
389. Case Report: When “Normal” Cholesterol is Not Normal: Exposing an Unusual Presentation of Fa...
388. Ironing out the Data: Iron Deficiency in Heart Failure with Dr. Robert Mentz
มุมมอง 342 หลายเดือนก่อน
388. Ironing out the Data: Iron Deficiency in Heart Failure with Dr. Robert Mentz
387. Cardio-Rheumatology: The Role of Inflammation in Cardiovascular Disease with Dr. Antonio Abbate
มุมมอง 42 หลายเดือนก่อน
387. Cardio-Rheumatology: The Role of Inflammation in Cardiovascular Disease with Dr. Antonio Abbate
386. Beyond the Boards: Cardiomyopathies with Dr. Steve Ommen
มุมมอง 192 หลายเดือนก่อน
386. Beyond the Boards: Cardiomyopathies with Dr. Steve Ommen
385. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #34 w...
มุมมอง 122 หลายเดือนก่อน
385. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #34 w...
384. Case Report: Little (a), Big Deal - National Lipid Association
มุมมอง 102 หลายเดือนก่อน
384. Case Report: Little (a), Big Deal - National Lipid Association
383. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #33 w...
มุมมอง 22 หลายเดือนก่อน
383. Guidelines: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure - Question #33 w...
@ 11:00, why would you not discontinue the beta blocker? Surely it can reduce cardiac output, when can lead to more congestion ( due to elevated LVEDV). Thank you.
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Excellent discussion, this is such an "everyday case" that we see, and I really enjoyed all the clinical pearls. If I could just ask a few quick questions: 1) When there's a patient with a systolic BP of 90 on double pressors, there's often hesitation in giving a large lasix dose (such as 80-100 mg) as a stress test. Is this fear warranted, and can the lasix dose by itself worsen hemodynamics? 2) Regarding late-start dialysis, a lot of the cardiac ICU patients whom I see tend to require dialysis initiation simply because of a large positive fluid balance (and not for uremia/hyperkalemia/acidosis), which results in an increased pre-load and worsening hemodynamics. In this situation, when the filling pressures are rising, the urine output is falling and the lasix isnt working, I find that starting earlier makes it easier to control fluid balance. I find this hard to reconcile with all the data showing a late start is better. Should I be waiting longer, and how long is it safe to wait, since "volume overload" is a bit of a subjective call? 3) Is there a lower limit of BP below which you dont start CRRT? Say the patient's on triple supports and the systolic BP is 60 - do you wait for the patient to stabilise, or go right ahead with CRRT? Thanks so much again for the really fantastic overview !
Wherever salt goes, [Dr Topf], water follows, [renal fellow]. Sweet episode. Enjoying listening to this so far.. The cardio-renal connection that we all needed!
Thank you, this helps a lot!
I was hoping that you would talk about a note on how to use the citation tools. Would appreciate if there is a another video even briefly talking about those thank you very very much for for all all you do.
Thanks so much for sharing this with the public!
"Promo sm"
I recently underwent emergency open heart surgery…I just happened on. this channel by coincidence…
Amazing explanation, thank you very much
❤
He is such an inspiration. Currently working my way to medical residency and his played a huge role in disciplining me!
Great help for Infographic-building-beginning
Plz
Hello mam how to contact with u can u give me ur email I need ur help plz mam
thank you so much
Very useful. Thanks for this video!
Thank you..it was helpful
The best teacher! Doctor Rhanderson. :)
I cannot thank you enough
you're speaking so delicately... who are you and what have you done with ahmed ghoneem?
Amazing work, great explanation. Love it
Amazing video! 👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻
Great presentation. Thank you Dr Zheng!
In the third patient, float a Swan and give fluid guided by the wedge?! Or give fluid in 250ml aliquots with serial evaluation of neck veins?!
Nice
Super sir
Fantastic video Dr Isakadze thank you kindly
th-cam.com/video/V9uwXOZEt6o/w-d-xo.html
what's the reason for the abnormally rapid filling in early diastole?
late diastolic filling is not possible due to pericardial issue thus whatever filling has to occur must occur in Systolic phase of venous return & EARLY 1/3rd diastolic phase of Venous return, in short its compensatory increase.
💞💞💞💞
Amazing work 👏, very helpful Thank you Dr.Abdulhamied
Best and easiest explaination of Constrictive pericarditi's features. Thanks
Lovely presentation very good cae👏😊
They aren't taking enough aboit covid myocarditis, it's more common than most realize in ex covid patients
yet this condition is triggered by the 💉
@@SedriqMiers yes it is also! Both the virus and the vaccine give this.
Nice
Truly epic job, Dr. Isakadze. Thank you so much for such timely teaching.
Very useful overview. Precisely what criteria are used to decide the need for mechanical circulatory support?
Great question. Lots of nuances there. We will be tackling this subject more in depth on a podcast in the future. Check out our heart failure series www.cardionerds.com/episodes/heart-failure-awareness-cardionerds-series/ for more information about advanced therapies in heart failure.
Great question, thanks for asking. It's a very difficult decision as noted previously. You need to factor in the patient and their comorbidities, the state of their heart, and the severity of what process they are going through. Patients who require MCS are usually failing medical therapy (ie, persistently hypotensive, low output, not clearing lactate, end organs are underperfused). Then you have to assess what the goal or endpoint is, whether it's as a bridge to recovery (such as a patient with a transient process you think will reverse) or a bridge to a definitive treatment, which could include a transplant, LVAD, high risk PCI, VT ablation, just as a few examples. You then need to assess the patient and their comorbidities to consider how they would fare on MCS and whether they would be a candidate for the definitive therapies above. It's a complex that decision that needs coordinated input from the primary team, intensitivist, and interventionalists/heart failure specialists and of course the patient/family themselves.
@@balintlaczay6816 Thanks for your reply. I am not sure about adult data, but certainly in pediatrics there's good evidence to show that early use of MCS has better outcomes than waiting for organs to start failing.
@@sanaullah6911 Of course, thanks for clarifying. There are certainly differences in pediatrics and adults which I'm not the best one to clarify. And as for "waiting for organs to fail" what I meant to say is that end organ malperfusion is what often leads providers to pull the trigger on MCS. There are of course occasions where based on clinical trajectory or anticipated procedures MCS is pursued earlier in the clinical course.
Well done!!
Loved it. Always got your back
👍
Amazing confidence
Very interesting.